Effects of resistance exercise training on cognitive function of diabetes patients after laparo-scopic surgery
Objective To investigate the effects of resistance exercise training on cognitive func-tion and serum triggering receptor expressed on myeloid cells 2(TREM2),nuclear factor κB(NF-κB),signal transducer and activator of transcription 3(STAT3)of diabetic patients after laparoscopic surgery.Methods A total of 118 patients with type 2 diabetes who underwent laparoscopic surgery at Suzhou Ninth People's Hos-pital from April 2022 to December 2023 were randomly divided into two groups.The control group(n=59)re-ceived routine intervention after surgery,while the training group(n=59)received resistance exercise training for 2 consecutive weeks post-surgery.The Montreal Cognitive Assessment(MoCA)was conducted at 1 day,1 week,and 2 weeks after surgery,with a MoCA score of<26 indicating cognitive dysfunction.Additionally,forced expiratory volume at 1 second(FEV1)/forced vital capacity(FVC),minute ventilation volume(MVV)and left ventricular ejection fraction(LVEF),serum albumin,alanine aminotransferase,aspartate aminotransferase,glucose,creatinine,urea,uric acid,interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),TREM2,NF-κB,STAT3 levels were measured 2 weeks post-surgery.Results One day after surgery,there was no significant difference in MoCA scores between the two groups(P>0.05).At one and two weeks after surgery,the MoCA score in the training group was higher than that in the control group,the difference was statistically significant(P<0.05).Additionally,the incidence of cognitive dysfunc-tion was lower in the training group compared to the control group,and the difference was statistically sig-nificant(P<0.05).At two weeks after surgery,there were no significant differences in serum albumin,ala-nine aminotransferase,aspartate aminotransferase,glucose,creatinine,urea and uric acid between the two groups(P>0.05).The levels of serum IL-1β,IL-6,TNF-α,TREM2,NF-κB,and STAT3 in the training group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Resistance exercise training improves cognitive function in diabetic patients after laparoscopic surgery and reduces the incidence of cognitive dysfunction.The inhibition of inflammation mediated by the TREM2/NF-κB/STAT3 pathway is a possible molecular mechanism.
NETL
NSTL
万方数据
