The expression of serum AGEs and sRAGE in patients with autoimmune liver disease and its relationship with liver function and disease activity
Objective To investigate the expression of serum advanced glycation end products(AGEs)and soluble advanced glycation end product receptor(sRAGE)in patients with autoimmune liver dis-ease(AILD)and its relationship with liver function and disease activity.Methods 148 AILD patients admit-ted to Beijing You'an Hospital affiliated with Capital Medical University from March 2020 to October 2023 were selected as the study subjects(AILD group).They were divided into an active group(n=102)and a re-mission group(n=46)based on different disease activity levels.Additionally,150 healthy individuals who un-derwent physical examinations at our hospital during the same period were selected as the control group.A fully automated biochemical analyzer to was used to detect liver function indicators such as aspartate amino-transferase(AST),alanine aminotransferase(ALT),and total bilirubin(TBIL)levels.Enzyme linked immu-nosorbent assay was used to detect serum AGEs and sRAGE levels.Pearson correlation analysis was used to ex-plore the correlation between serum AGEs,sRAGE levels,and liver function indicators in AILD patients.The predictive value of serum AGEs and sRAGE for disease activity in AILD patients was evaluated using receiver operating characteristic(ROC)curves.Results The serum AGE levels in the ALDS group were significantly higher than those in the control group,and the sRAGE levels were significantly lower than those in the control group,with statistical significance(P<0.05).The serum levels of AST,ALT,and TBIL in the ALDS group were higher than those in the control group,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that serum AGE levels in patients with AILD was positively correlated with AST,ALT,and TBIL(0.371),while serum sRAGE levels were negatively correlated with AST,ALT,and TBIL(P<0.05).The serum AGE levels in the activity group were significantly higher than those in the remission group,and the sRAGE levels were significantly lower than those in the remission group,with statistical sig-nificance(P<0.05).The area under the curve(AUC)of serum AGEs and sRAGE predicting disease activity in ALDS patients was 0.852 and 0.767,respectively,which were lower than the combined prediction of the two(0.902).Conclusion The increase in serum AGE and sRAGE levels is closely related to liver function and disease activity in patients with AICD.they can serve as important indicators for predicting disease activity in these patients.
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