Advances of Mass Spectrometry Analysis for Small Molecular Illegal Additives in Health Care Products
With the increasing aging of the population,the global health product industry has developed rapidly in the few decades.The opacity of raw materials and gift properties of health care products lead to extremely high profits in the health products industries.To pursue economic benefits,some illegal manu-facturers illegally add prohibited small molecular compounds with biological activities to health care prod-ucts to improve their efficacy,which has serious hidden dangers and threats to consumers'health and e-ven life safety.Therefore,the establishment of accurate and rapid detection methods for illegal small mo-lecular additives in health care products is of great significance for the quality control of health care prod-ucts and safety of consumers.However,the complex chemical composition of health care products makes them difficult to detect specific additives.As the main method of qualitative and quantitative detection of small molecule agents in complex matrix,mass spectrometry and its associated combined technologies have obvious advantages in the detection of illegal small molecular additives in health care products.The applications of mass spectrometry in the detection of illegal small molecular additives in health products are introduced,and the future development direction of detection technologies are also prospected.Fur-thermore,the influence of dosage forms and complex substrates on detection,the establishment of high-throughput detection methods and the detection of derivatives should be focused on in the future.
instrument analysismass spectrumhealth care productsillegal chemical additivesfood and drug supervision
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