With the development of socio-economic development,the number of high-rise buildings is increasing in China.Energy dissipation and seismic isolation technologies have gradually been applied in high-rise structures.In addition,it proposes a new combination of seismic dissipation and isolation devices.This article is to study the effects of the layout of dampers in the high-rise composite seismic dissipation and isolation structure.Four aseismic schemes are selected for a frame-core wall structure in high seismic region:The traditional aseismic,seismic isolation,seismic isolation-isolation layer dissipation and seismic isolation-non-isolation layer dissipation,and 7 earthquake waves are selected to analyze the elastic-plastic time-history of rare and extremely rare seismic through software Perform-3D.Comparison the structure macro indicators found:Compared with the aseismic structure,the combined seismic isolation structure can effectively reduce the seismic response;the composite structure with viscous damper installed in the non-isolated layer has the best aseismic effect and improves the safety of the structure.