Aiming at the multi-modal and multi-channel input of brain tumor segmentation task,a 3D u-net model with spatial per-ception focus loss function and Soft Dice loss function is proposed.The addition of spatial awareness improves the segmentation weight for important partition and improves the segmentation effectiveness of important partition.The model uses Dice coefficient and HD95(Hausdorff Distance 95th percentile)as evaluation criteria.Compared with 3D U-Net on BraTS2021 dataset,the Dice co-efficient of tumor core increases by 3.21%,the Dice coefficient of complete tumor increases by 2.49%,the Dice coefficient of en-hanced tumor increases by 3.1%,and the HD95 coefficient decreases by 4.90,showing the excellent segmentation ability of the model.