At present, the courses for cultivating teacher students'scientific reasoning ability are often di-vorced from real scientific inquiry. Based on this, this study reformed the"physical experiment teaching ability training" course for the physics teacher major of A Normal University and introduced the argument-driven in-quiry (ADI) teaching model. After a semester of study, the epistemic network analysis method was applied to analyze the change of scientific reasoning ability of teacher students. The result shows that this teaching mode can improve the scientific reasoning ability of teacher students. This provides a feasible scheme for cultivating teacher students'scientific reasoning ability and improving their quality in real scientific inquiry activities.