Relying on multiple unit engineering projects for the renovation of a critical bridge in a specific region of Guangdong Prov-ince,this study addresses the challenges associated with pile foundation construction in complex karst geology in the northern mountainous ar-eas of the province.The issues encountered include grout leakage and sinkholes.Different principles for treating karst caves with varying heights and filling states,as well as optimization schemes for pile foundation design,were proposed.The results indicate that for the first critical bridge in the project,the use of clay backfill and the steel casing follow-up method effectively resolved issues related to single small to medium-sized karst caves.However,for the second critical bridge in the project,which had a larger number of interconnected karst caves,avoidance measures were implemented,and the pile foundation was optimized to a double-row friction pile design.This approach sig-nificantly reduced the cost of karst cave treatment and ensured construction safety.Based on the results of core drilling and perforation test-ing,it is concluded that the karst cave treatment measures and the optimized pile foundation design adopted in this project ensure the integri-ty and good quality of the piles,meeting the required standards for construction.