摘要
目的 探讨代谢因素与胆囊结石伴急性胆囊炎的相关性和诊断价值.方法 以本院2020年1月到2023年1月收治的胆囊结石患者进行回顾性分析,将胆囊结石伴急性胆囊炎患者为研究组,同期胆囊结石伴慢性胆囊炎患者为对照组,对研究对象的一般资料、既往史、临床资料进行收集和统计学分析,并运用多因素二元Logistic回归和ROC曲线分析代谢因素与胆囊结石伴急性胆囊炎的相关性和诊断价值.结果 总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、空腹血糖(FBG)、中性粒细胞(N)、中性粒细胞与淋巴细胞计数比值(NLR)、血小板计数(PLT)、血小板压积(PCT)、总胆红素(TBIL)、直接胆红素(DBIL)代谢指标是胆囊结石伴急性胆囊炎发病独立危险因素.其中TC、TG、HDL-C、FBG、NLR、TBIL、DBIL的敏感性均达70％以上;TG、HDL-C、FBG、N、NLR、PLT的特异性均达90％以上.结论 本次研究结论表明代谢因素与胆囊结石伴急性胆囊炎存在明显的相关性,在临床工作中应加强肝胆疾病与内科疾病的控制及治疗,有效控制代谢相关疾病,以预防胆囊结石伴急性胆囊炎的复发.
Abstract
Objective To explore the correlation and diagnostic value of metabolic factors and gallstones with acute cholecysti-tis.Method The patients with gallstones admitted to our hospital from January 2020 to January 2023 were retrospectively analyzed.The patients with gallstones and acute cholecystitis were the study group,and the patients with gallstones in chronic cholecystitis in the same period were the control group.The general data,past history and clinical data of the subjects were collected and statistically ana-lyzed.Multivariate binary logistic regression and ROC curve were used to analyze the correlation and diagnostic value of metabolic fac-tors and gallstones with acute cholecystitis.Results Total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C),fasting blood glucose(FBG),neutrophil(N),neutrophil to lymphocyte count ratio(NLR),platelet count(PLT),plate-let hematocrit(PCT),total bilirubin(TBIL),direct bilirubin(DBIL)metabolic indicators are independent risk factors for gall-bladder stones with acute cholecystitis.The sensitivity of TC,TG,HDL-C,FBG,NLR,TBIL and DBIL was more than 70％.The specificity of TG,HDL-C,FBG,N,NLR and PLT was more than 90％.Conclusion The conclusions of this study show that there is a significant correlation between metabolic factors and gallstones with acute cholecystitis.In clinical work,the control and treatment of hepatobiliary diseases and medical diseases should be strengthened to effectively control metabolic-related diseases and prevent gall-stones with acute cholecystitis recurrence.
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