2010-2021年广州市初治HIV感染者糖脂代谢异常患病趋势及其年龄-时期-队列模型分析
Trends in abnormal glucose and lipid metabolism among newly treated HIV-infected patients and age-period-co-hort model analysis in Guangzhou,2010-2021
尚萌琳 1谢今朝 1王旭 1刘聪 2钟海丹 2杜佩珊 2李全敏 2蔡卫平 2李凌华 2顾菁1
作者信息
- 1. 中山大学公共卫生学院,广东广州 510000
- 2. 广州市第八人民医院感染病中心
- 折叠
摘要
目的 分析2010-2021年广州市初治HIV感染者糖脂代谢异常患病率的变化,探讨性别、年龄、时期、队列因素的影响.方法 基于广州市第八人民医院2010-2021年16 454例初治HIV感染者数据,采用Join-point回归模型分析糖代谢异常、甘油三酯代谢异常、胆固醇代谢异常的患病率变化趋势,采用年龄-时期-队列模型分析患病率变化的影响因素.结果 16 454例初治HIV感染者中,平均年龄(36.78±12.07)岁,男性13 783例(83.8％).2010-2021 年期间初治 HIV感染者糖代谢异常(AAPC=-2.4％,95％CI:-5.31％～0.50％,P=0.103)、甘油三酯代谢异常(APC=AAPC=-4.13％,95％CI:-7.59％～-0.54％,P=0.029)、胆固醇代谢异常(APC=AAPC=-13.47％,95％CI:-16.03％～-10.84％,P＜0.001)患病率整体均呈下降趋势,女性脂代谢异常患病率高于男性.年龄-时期-队列模型结果显示,糖代谢异常、甘油三酯代谢异常的患病率在40～50岁最高,胆固醇代谢异常患病率随年龄增大逐渐下降;糖脂代谢异常的患病率随时期整体呈下降趋势;较早出生队列的人群糖脂代谢异常的患病率较高.结论 近年来初治HIV感染者糖脂代谢异常负担整体降低,但仍应加强对糖代谢异常的防控.女性、中老年群体、较早的感染者是糖脂代谢异常的高危群体.
Abstract
Objective To analyze the changes in the prevalence of abnormal glucose and lipid metabolism among newly treated HIV-infected patients in Guangzhou from 2010 to 2021,and explore the influence of gender,age,period,and cohort factors.Methods Based on the treatment data of 16 454 newly treated HIV-infected patients at Guangzhou Eighth People's Hospital from 2010 to 2021,the trends in the prevalence of abnormal glucose,triglyceride,and cholesterol metabo-lism were analyzed by using Joinpoint regression,and the influencing factors of prevalence change were analyzed by using age-period-cohort model.Results Among the 16 454 newly treated HIV-infected patients,the mean age was(36.78±12.07)years old,and 13 783(83.8％)were males.From 2010 to 2021,the prevalence of abnormal glucose metabo-lism(AAPC=-2.4％,95％CI:-5.31％-0.50％,P=0.103),abnormal triglyceride metabolism(APC=AAPC=-4.13％,95％CI:-7.59％--0.54％,P=0.029),and abnormal cholesterol metabolism(APC=AAPC=-13.47％,95％CI:-16.03％--10.84％,P＜0.001)showed a downward trend.The prevalence of abnormal lipid metabolism in females was higher than that in males.The results of the age-period-cohort model showed that the prevalence of abnormal glucose metabolism and triglyceride metabolism was highest in the age of 40-50 years,the prevalence of abnormal cholesterol metabolism gradually declined with age;the prevalence of abnormal glucose and lipid metabolism showed an overall decreasing trend with the period;and the prevalence of abnormal glucose and lipid metabolism was higher in the population of the earlier birth co-hort.Conclusions The overall burden of abnormal glucose and lipid metabolism among newly treated HIV-infected pa-tients has decreased in recent years.However,there is a need to enhance the prevention and control measures for abnormal glucose metabolism.Females,middle-aged and older groups,and earlier infected individuals are at high risk for abnormal glucose and lipid metabolism.
关键词
抗病毒治疗/HIV/糖脂代谢异常/Joinpoint/回归模型/年龄-时期-队列模型Key words
Antiretroviral therapy/HIV/Abnormal glucose and lipid metabolism/Joinpoint regression model/Age-period-cohort model引用本文复制引用
基金项目
国家科技重大专项(十三五)(2018ZX10715004)
出版年
2024
NETL
NSTL
万方数据