Construction and Application of Polylysine Peptide Modified Gelatin Multifunctional Hydrogel
The ε-polylysine(EPL)antibacterial peptide was grafted onto gelatin to synthesize EPL-modified gelatin(GEL-E),afterwards,a multifunctional hydrogel,GEL-E/CMC/OCS hydrogel,with injectable,self-healing and antibacterial properties was prepared using GEL-E,carboxymethyl chitosan(CMC)and chondroitin oxysulfate(OCS).The experimental results showed that the hydrogel prepared has high energy storage modulus,elastic deformation,self-healing,injectable and antibacterial properties.Dipotassium glycyrrhizinate(DG)was loaded into hydrogel,which endowed the hydrogel with anti-inflammatory properties and wound healing ability.The results showed that the drug release rate could reach 100%.Meanwhile,the cell compatibility and the ability of promoting cell migration were evaluated,the results showed that the hydrogels presented very low cytotoxicity and could promote cell migration.All the above results indicated that the GEL-E/CMC/OCS hydrogel has good mechanical properties,biocompatibility and ability to promote cell migration,and has broad application prospects in the field of promoting wound healing.
国家科技期刊平台
NSTL
万方数据
维普
