Manganese-induced Radical Cyclization of 1-Isocyano-2-[1-(trifluoromethyl)ethenyl]benzenes to Access 4-CF3-Quinoline Derivatives
A new Mn(Ⅲ)/Mn(Ⅱ)induced reaction was developed,which involves a radical 6-endo-trig cyclization of 1-isocyano-2-[1-(trifluoromethyl)vinyl]benzene with arylboronic acid and catalyzed by manganese.Various 4-CF3-2 arylquinolines were obtained with high regioselectivity,chemical selectivity and mild condition without any exter-nal oxidants,ligands,or additives.
万方数据
