Photorelease and Antioxidant Activity of Avobenzone-Ferulic Acid
Ferulic acid is an effective antioxidant that is widely used in the cosmetics due to its ability to resist oxidative stress and delay skin aging.However,its photosensitivity challenges its application.In order to overcome this limitation,we developed a binary molecule composed of avobenzone(AB)and ferulic acid(FA).This design is based on the existence of photoremovable benzoyl methyl in the avobenzone to protect ferulic acid from photodamage and maintain its antioxidant activity.The results showed that FA was successfully released,and AB had an effectively photoprotective effect on FA.In vitro experiments showed that AB-FA molecules and their photolysis products had significant activity of scavenging free radical,while cell experiments confirmed their low cytotoxicity and excellent ability to reactive oxygen species(ROS)scavenging.
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