Photoinduced Trifluoromethyl/arylation Reaction of Carbon Carbon Double Bond Involving CF3Br for the Synthesis of CF3-substituted 1,1-Diaryl Alkane Derivatives
A synergistic catalytic strategy combining photocatalysis and transition metal catalysis was employed to achieve the carbon carbon double bond trifluoromethyl/arylation reaction in which the inexpensive and readily available bromotrifluoromethane and aromatic amines were used as substrates.A series of potentially biologically active CF3-substituted 1,1-diaryl alkane derivatives was synthesized.This work explores the possibility of aromatic amines as arylation reagents,enriches the types of arylation reagents,clarifies the conditions for the arylation process and explores the reaction mechanism.This method has the characteristics of simple operation,low cost and easy availability,providing a concise and effective approach for the synthesis of trifluoromethyl substituted 1,1-diaryl alkanes derivatives.
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