Synthesis of Carbon Nanopolymers Based on Deep Eutectic Strategy for Simultaneous Electrochemical Detection of a Variety of Biological Small Molecules
A conductive polymer material poly(3,4-ethylene dioxythiophene)(PEDOT)was synthesized based on a deep eutectic strategy and combined with gold nanoparticles(Au NPs)to construct a novel electrochemical sensing platform to realize the simultaneous determination of a variety of small biological molecules[ascorbic acid(AA),dopamine(DA),uric acid(UA)].The morphology,performance and effective area of glassy carbon electrode modified by PEDOT and Au NPs(PEDOT-Au/GCE)were characterized.The experimental results show that the modified electrode can achieve simultaneous detection of AA,DA and UA with high sensitivity and high stability,proving that the PEDOT-Au NPs complex has good electrochemical catalytic activity.Under optimal experimental conditions,the concentration and peak current value of AA,DA and UA in mixed solution show a good linear relationship in the concentration ranges of 100-1000,50-500 and 22.5-225 μmol/L,respectively,with the separate detection limits of 21,0.38 and 0.016 μmol/L.In addition,the electrochemical sensing platform has a high specificity for AA,DA,and UA in the presence of other active small molecules in serum.This method is applied for the recovery determination of AA,DA and UA in serum samples.
Deep eutectic strategyPoly(3,4-ethylene dioxythiophene)(PEDOT)Electrochemical sensorSmall biological molecule
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