[3+2]Cyclization Addition of N-cyclopropyl Aniline in a Non-metallic Photocatalytic System
Cyclopentane structure is widely present in natural products and drug molecules,and is one of the important core skeletons in the synthesis of small molecule drugs.In this conversion,19 kinds of cyclopentane derivatives were obtained with good to excellent yields and satisfied diastereoselectivity using N-cyclopropylaniline and 2-[acetoxy(phenyl)methyl]acrylate as starting materials.It is worth mentioning that one pure distereoisomer could be separated just by column chromatography.This protocol features mild conditions,broad substrate scope,green economy,giving a new pathway for the synthesis of cyclopentane and new application of Eosin Y in the field of photocatalytic synthesis.
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