首页|Improved Synthesis of Icaritin and Total Synthesis of β-Anhydroicaritin
Improved Synthesis of Icaritin and Total Synthesis of β-Anhydroicaritin
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Natural products icaritin and β-anhydroicaritin with P-glycoprotein(P-gp) inhibitory activities were efficiently synthesized in nine steps from commercially available phloroglucinol.A modified Algar-Flyrm-Oyamada cyclization and relay Claisen-Cope rearrangement were employed in this concise route.Our synthesis offers opportunities to synthesize various icariin analogues for biological and pharmacological investigations.
CAS Key Laboratory of High-performance Synthetic Rubber and Its Composite Materials, Key Laboratory of Green Chemistry and Process of Jilin Province, Changchun Institute of Applied Chemistry,Chinese Academy of Sciences, Changchun 130022, P.R.China
University of Chinese Academy of Sciences, Beijing 100049, P.R.China
University of Science and Technology of China, Hefei 230026, P.R.China
Supported by the National Natural Science Foundation of China
NETL
NSTL
万方数据
维普
