查看更多>>摘要：With the excessive use of fossil fuels leading to significant CO2 emissions,and the continuous increase of NOx in water bodies and soils,the use of electrochemical methods for the conversion of CO2 and NOx has garnered widespread attention as a green chemical approach due to its advantages of being environmentally friendly,low-carbon,and straightforward.C-N bonds are widely present in many value-added chemicals,such as urea,amides,and oximes.However,traditional methods for constructing C-N bonds typically involve thermochemical processes.Therefore,using electrochemical methods to catalyze the reduction of CO2 and NOx for C-N bond formation has emerged as a green and sustainable alternative.This paper summarizes the research progress of electrochemical C-N bond construction involving CO2 and NOx from the perspectives of reaction mechanisms and catalytic system construction,reviews the electrochemical synthesis of urea,amines,amides,and oximes through electrochemical C-N bond construction,and finally analyzes the current problems and challenges in the field,providing prospects for its future development.
查看更多>>摘要：Vascular embolization treatment,a minimally invasive surgery for various blood vessel-related conditions,has emerged as a crucial method in treating such as hemorrhage,arteriovenous malformation,aneurysms,and hypervascular tumors.Liquid embolic agents are gaining prominence due to their distinct advantage in infiltrating distal regions,expanding the scope of embolization beyond the reach of solid agents.Recent strides in biomaterials and technologies have spurred the development of novel liquid embolic agents,addressing challenges posed by traditional options.This mini-review provides a concise overview of the recent progress in water-based liquid embolic agents,highlighting their potential to overcome limitations associated with current embolic materials.By presenting selected research outcomes,we illuminate advancements that enhance the efficacy of liquid embolic agents.Furthermore,the review outlines essential properties for effective liquid embolic agents,offering insights for future developments in this field.
查看更多>>摘要：In recent years,tissue scaffolds have emerged as a new therapeutic method for bone and cartilage regeneration,with sponge scaffolds gaining increasing attention.Sponge scaffolds possess several favorable characteristics,including appropriate biodegradability,excellent biocompatibility,good processability,powerful osteogenic ability,a unique porous structure,and adjustable pore size and connectivity.These attributes make sponge scaffolds a promising option for bone and cartilage regeneration.However,to date,there is a lack of comprehensive reviews summarizing the use of sponge scaffolds in this field.In this review,our objective is to provide a comprehensive overview of the research progress and development trends of sponge scaffolds.Firstly,we introduce the various materials used for sponge scaffolds.Secondly,we summarize the different preparation methods employed for creating sponge scaffolds.Subsequently,we discuss the functional additives that can be incorporated into the scaffolds.Finally,we present some special structures that can be achieved in sponge scaffolds.Our aim is for this review to offer valuable insights and serve as a comprehensive resource for the design of sponge scaffolds in cartilage and bone regeneration.
查看更多>>摘要：This brief review highlights the techniques and diverse applications of time-resolved electron paramagnetic resonance(TREPR)spectroscopy,underscoring its essential role in elucidating the structures,spin dynamics,and reactivities of open-shell systems.Furthermore,we discuss the limitations of traditional TREPR methodologies,particularly their challenges in directly observing reactive radical intermediates under real-world reaction conditions.Lastly,we present the latest advancements in TREPR technology developed in our laboratory,specifically ultrawide single-sideband phase-sensitive detection(U-PSD)TREPR,highlighting its significant impact and tremendous potential in advancing free radical chemistry research.We envision promising future applications of TREPR and its pivotal role in enhancing our understanding of mechanisms involved in complex radical processes and photocatalysis.
查看更多>>摘要：Chemiluminescence,a phenomenon emitting light from chemical reactions rather than photon absorption,has gained significant interest for applications in bioimaging and biosensing due to its high sensitivity and low background interference.Now there is a growing interest in near-infrared(NIR)chemiluminescent probes for improved tissue penetration and reduced autofluorescence.This review summarizes NIR emissive chemiluminescent probes based on 1,2-dioxetane and discusses their chemical structures and applications.Structure modification strategies for red-shifting wavelength and enhancing brightness include incorporating electron-withdrawing groups,designing chemiluminophore-fluorophore cassettes,and exploring alternative chemiluminescent scaffolds.This review aims to inspire the exploration of NIR chemiluminescent probes in disease detection and treatment.
查看更多>>摘要：Non-invasive bioelectronics,especially organic electrochemical transistors(OECTs),have drawn extensive attentions of academical and medical communities by virtue of their efficient bio-electronic interfacing,water-involved ionic transport,excellent ionic-electronic coupling,ultralow power consumption,wide detectable range,and outstanding detection sensitivity.Designable structure diversity,low-temperature solution processability,facile bio/chemical functionalization,and excellent biocompatibility of organic mixed ionic-electronic conductors(OMIECs)render OECTs particularly suitable for non-invasive or minimally invasive healthcare analytical platform.Here,we comprehensively review recent advances of the non-invasive analytical healthcare applications based on OECTs,especially on the detection of biomarkers or metabolites in the excretory biofluids,as well as the recording of electrophysiological signals.A brief introduction of OECT and its comparison with other organic thin-film transistors upon device configuration and working mechanism are firstly discussed.State-of-the-art non-invasive OECT-based biosensors are summarized on their detection of ionic and molecular biomarkers,following with circuit design strategies of OECTs for real-time and in-situ electrophysiological recording from skin surface.In conclusion,remaining barriers and future challenges of non-invasive OECT-based bioelectronics towards lower detection limit,more accurate quantitative relationship between analyte concentrations and measured parameters,more intimate device-tissue interface,and long-term operation stability are deeply analyzed with a critical outlook.
查看更多>>摘要：Chiral metal-organic cages(MOCs)serve as a representative model for enzyme simulation,offering a robust platform for reproducing and expanding enzyme functions at the molecular level.In this study,we present a family of lanthanide triple-stranded helicates with finely-tuned stereoconfigurations,self-assembled from ligands featuring both point and axial chiral centers.Circular dichroism(CD)and circularly polarized luminescence(CPL)spectroscopy demonstrated that peripheral point chirality induces the stereoconfiguration(Δ/Λ)of the metal center,while bridging axial chirality defines the cavity chiral microenvironment,resulting in the formation of both homochiral and mesomeric helicates.In comparison to mesocate,the homochiral helicates exhibited heightened enantioselectivity in the luminescent detection of D/L-leucinol.
查看更多>>摘要：Actin fibers are an important part of the cytoskeleton,providing vital support for the plasma membrane.This function is driven by its ATPase(ATP:adenosine triphosphate)activity,i.e.,ATP+H2O→ADP+Pi.This seemingly simple reaction has attracted much attention because the hydrolysis of ATP provides energy to support life processes.However,the reaction mechanism of ATP hydrolysis in actin is not clear.In order to gain deep insights into the functions of actin,it is essential to elucidate the reaction mechanism of the actin ATP hydrolysis.In this paper,we have studied the reaction mechanism of the ATP hydrolysis in actin by the combined quantum mechanical and molecular mechanics(QM/MM)calculations.Our results show that 1)bond cleavage of the Pγ-Os of ATP and bond formation between oxygen of the lytic water and Pγ atomstake place simultaneously,and this is the rate-limiting step of the hydrolysis;2)the proton on the lytic water transfers to the phosphate to form H2PγO4-via one bridge water.The energy barrier of the complete reaction is 17.6 kcal/mol(1 kcal=4.184 kJ),which is in high agreement with the experimental value.
查看更多>>摘要：Developing green and well-controlled polymerization methods is of great significance for the preparation of biomedical polymer materials.In this contribution,an efficient organocatalytic ring-opening polymerization(ROP)of a class of seven-membered cyclic carbonates(T6DO,T6HDO,C6DO,C6HDO)containing cis-or trans-cyclohexane structure was established.Organic catalyst 1,5,7-triazabicyclo[4.4.0]dec-5-ene(TBD)promoted living polymerization of these cyclic carbonates to deliver polycarbonate and block copolymer products with predictable molecular weights and narrow dispersity.The robust TBD-mediated ROP at 90 ℃ showcased turnover frequency(TOF)up to 103 h-1.The resulting amorphous polycarbonates displayed good thermal stability.
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