首页|Tea Polyphenols Reducing Lipopolysaccharide-induced Inflammatory Responses in RAW264.7 Macrophages via NF-κB Pathway

Tea Polyphenols Reducing Lipopolysaccharide-induced Inflammatory Responses in RAW264.7 Macrophages via NF-κB Pathway

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The anti-inflammatory activity of tea polyphenols(TPs) in RAW264.7 macrophages stimulated by lipopolysaccharide(LPS) was investigated in this paper.RAW264.7 macrophages were treated with different concentrations of TP(0,12.5,25,50,100,and 200 μg/mL) and then stimulated by LPS.Another blank control group was set up.The expression of pro-inflammatory cytokines associated with the nuclear factor-kappa B(NF-κB) signaling pathway was investigated before and after TP treatment.Pretreatment of RAW264.7 cells with TP decreased the expression of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin 1 beta(IL-1β) pro-inflammatory cytokines.In addition,TP inhibited the phosphorylation of p65 and IκB by blocking the phosphorylation and the degradation of NF-rB inhibitor protein.In conclusion,TP exerts anti-inflammatory effects by regulating the release of inflammatory mediators via the NF-κB signaling pathway.

Tea polyphenolInflammatory responseRAW264.7Nuclear factor-kappa B pathway

SU Siyi、LI Xiaoyu、GUO Xu、ZHOU Ruiming、LI Manman、MING Pengfei、HUANG Yingying、Sajid Ur RAHMAN、DING Hongyan、FENG Shibin、LI Jinchun、WANG Xichun、LI Yu、WU Jinjie

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College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, P.R.China

Supported by the National Key Research and Development Program of ChinaSupported by the National Key Research and Development Program of ChinaTraining Program of Innovation and Entrepreneurship for Undergraduates of Anhui Agricultural University,China

No.2016YFD0501009No.XJ2015168

2019

高等学校化学研究(英文版)
吉林大学

高等学校化学研究(英文版)

CSTPCDCSCDSCI
影响因子：0.871
ISSN：1005-9040
年,卷(期)：2019.35(6)
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