A Bird's Eye View of Quantitative Proteome of Tumor Tissues from Lung Cancer Patients by a High Precision Mass Spectrometry Method

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外文摘要：Lung cancer produces a high incidence of malignant tumors.There have been many studies on lung cancer using mass spectrometry(MS)technologies.However,most studies have focused on humoral samples.In this work,26 pairs of tissue samples(tumor vs.para-tumor)from patients with lung cancer were analyzed using liquid chromatography-tandem MS(LC-MS/MS)with data-independent acquisition mode.In total,3152 proteins were quantified from tissue samples with high confidence,including 189 up-regulated and 522 down-regulated proteins(tumor vs.para-tumor).In addition,79 and 690 proteins were identified only in para-cancerous samples and cancerous samples,respectively.The results from bio-informatics tools indicated that altered proteins like PEBP1,HRG and LYZ could be ideal reservoirs for screening the potential biomarkers for lung cancer.It is believed these tissue-specific proteomics results will assist in the studies of lung cancer.

外文关键词：

Lung cancerProteomeData-independent aquisition

作者：

DU Xiaohui、LI Encheng、WANG Qi、YOU Xin

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作者单位：

Department of Scientific Research Center,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China

Department of Respiratory Medicine,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China

Lung Cancer Transitional Medicine Center,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of Chinathe"1+X"Program for Clinical Competency Enhancement-Interdisciplinary Innovation Project of the Second Hospital of Dalian Medica

项目编号：

8200331881903185819729162021RQ008

出版年：

2024

DOI：

10.1007/s40242-024-3246-y

高等学校化学研究(英文版)

吉林大学

高等学校化学研究(英文版)

CSTPCD

影响因子：0.871

ISSN：1005-9040

年,卷(期)：2024.40(1)

参考文献量27