高等学校化学研究(英文版)2024，Vol.40Issue(1) ：136-144.DOI:10.1007/s40242-024-3246-y

A Bird's Eye View of Quantitative Proteome of Tumor Tissues from Lung Cancer Patients by a High Precision Mass Spectrometry Method

DU Xiaohui LI Encheng WANG Qi YOU Xin
高等学校化学研究(英文版)2024，Vol.40Issue(1) ：136-144.DOI:10.1007/s40242-024-3246-y
✕
  • NETL
  • NSTL
  • 万方数据

A Bird's Eye View of Quantitative Proteome of Tumor Tissues from Lung Cancer Patients by a High Precision Mass Spectrometry Method

DU Xiaohui 1LI Encheng 2WANG Qi 3YOU Xin4
扫码查看

作者信息

  • 1. Department of Scientific Research Center,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China;Department of Respiratory Medicine,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China
  • 2. Department of Respiratory Medicine,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China
  • 3. Lung Cancer Transitional Medicine Center,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China;Department of Respiratory Medicine,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China
  • 4. Lung Cancer Transitional Medicine Center,The Second Affiliated Hospital of Dalian Medical University,Dalian 116023,P.R.China
  • 折叠

Abstract

Lung cancer produces a high incidence of malignant tumors.There have been many studies on lung cancer using mass spectrometry(MS)technologies.However,most studies have focused on humoral samples.In this work,26 pairs of tissue samples(tumor vs.para-tumor)from patients with lung cancer were analyzed using liquid chromatography-tandem MS(LC-MS/MS)with data-independent acquisition mode.In total,3152 proteins were quantified from tissue samples with high confidence,including 189 up-regulated and 522 down-regulated proteins(tumor vs.para-tumor).In addition,79 and 690 proteins were identified only in para-cancerous samples and cancerous samples,respectively.The results from bio-informatics tools indicated that altered proteins like PEBP1,HRG and LYZ could be ideal reservoirs for screening the potential biomarkers for lung cancer.It is believed these tissue-specific proteomics results will assist in the studies of lung cancer.

Key words

Lung cancer/Proteome/Data-independent aquisition

引用本文复制引用

基金项目

National Natural Science Foundation of China(82003318)

National Natural Science Foundation of China(81903185)

National Natural Science Foundation of China(81972916)

the"1+X"Program for Clinical Competency Enhancement-Interdisciplinary Innovation Project of the Second Hospital of Dalian Medica(2021RQ008)

出版年

2024
高等学校化学研究(英文版)
吉林大学

高等学校化学研究(英文版)

CSTPCD
影响因子：0.871
ISSN：1005-9040
参考文献量27
段落导航相关论文