Strategy for Detecting Systemic Treatment Sensitivity of Primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle

WU Jun ¹LI Yongzhi ¹QIN Hanjiao ²GAO Ying ³YANG Bing ³SHENG Jiyao ¹ZHANG Xuewen¹

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作者信息

1. Department of Hepatobiliary and Pancreatic Surgery,the Second Hospital of Jilin University,Changchun 130022,P.R.China
2. Department of Radiation Oncology,the Second Hospital of Jilin University,Changchun 130022,P.R.China
3. State Key Laboratory of Supramolecular Structure and Materials,Institute of Theoretical Chemistry,College of Chemistry,Jilin University,Changchun 130012,P.R.China
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Abstract

In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TPA).Furthermore,TPA-PEG2000 fluorescent nanoparticles were prepared via coating the shells with PEG2000.TPA-PEG2000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09％,indicating a high emission efficiency.Molecular biology experiments have confirmed its low toxicity and excellent biocompatibility.Increased cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced uptake.Therefore,the uptake of TPA-PEG2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

Key words

Nanoparticle/Near-infrared/Fluorescence/Systemic treatment sensitivity/Cell membrane fluidity

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基金项目

National Natural Science Foundation of China(82002809)

National Natural Science Foundation of China(81902484)

National Natural Science Foundation of China(52103209)

China Postdoctoral Science Foundation(2020M670864)

Medical and Health Talents Project of Jilin Province,China(2020SCZT097)

Youth Support Project of Jilin Association for Science and Technology,China(202028)

Jilin Provincial Science and Technology Development Plan,China(20210204028YY)

Natural Science Foundation of Jilin Province,China(YDZJ202301ZYTS080)

出版年

2024

高等学校化学研究(英文版)

吉林大学

高等学校化学研究(英文版)

CSTPCD

影响因子：0.871

ISSN：1005-9040

参考文献量49

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