首页|Strategy for Detecting Systemic Treatment Sensitivity of Primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle

Strategy for Detecting Systemic Treatment Sensitivity of Primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle

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In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TPA).Furthermore,TPA-PEG2000 fluorescent nanoparticles were prepared via coating the shells with PEG2000.TPA-PEG2000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09％,indicating a high emission efficiency.Molecular biology experiments have confirmed its low toxicity and excellent biocompatibility.Increased cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced uptake.Therefore,the uptake of TPA-PEG2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

NanoparticleNear-infraredFluorescenceSystemic treatment sensitivityCell membrane fluidity

WU Jun、LI Yongzhi、QIN Hanjiao、GAO Ying、YANG Bing、SHENG Jiyao、ZHANG Xuewen

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Department of Hepatobiliary and Pancreatic Surgery,the Second Hospital of Jilin University,Changchun 130022,P.R.China

Department of Radiation Oncology,the Second Hospital of Jilin University,Changchun 130022,P.R.China

State Key Laboratory of Supramolecular Structure and Materials,Institute of Theoretical Chemistry,College of Chemistry,Jilin University,Changchun 130012,P.R.China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationMedical and Health Talents Project of Jilin Province,ChinaYouth Support Project of Jilin Association for Science and Technology,ChinaJilin Provincial Science and Technology Development Plan,ChinaNatural Science Foundation of Jilin Province,China

8200280981902484521032092020M6708642020SCZT09720202820210204028YYYDZJ202301ZYTS080

2024

10.1007/s40242-023-3248-1

高等学校化学研究(英文版)
吉林大学

高等学校化学研究(英文版)

CSTPCD
影响因子：0.871
ISSN：1005-9040
年,卷(期)：2024.40(1)
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