首页|Open-vessel Synthesis of Poly-N-methoxyethylglycine
Open-vessel Synthesis of Poly-N-methoxyethylglycine
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Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic stability.One type of polypeptoids,poly-N-methoxyethylglycine(P-Nmeg),has been found to possess remarkable hydrophilicity and notable properties in terms of protein,cell,and bacterial antifouling.However,the currently known synthesis methods of P-Nmeg include solid-phase synthesis,which is time-consuming and difficult to scale up,and N-substituted N-carboxyanhydride(NNCA)ring-opening polymerization,whose monomers were difficult to store.In this study,we used the chemical stable Nmeg N-phenoxycarbonyl(NPC)as the monomer,which was obtained without the use of highly toxic reactants,such as phosgene or phosphorus halide,to synthesize P-Nmeg under open-vessel conditions.By adding BnNH2 as an initiator at 80 ℃,we can obtain controllable short chain length P-Nmeg with narrow dispersity.
LIU Guojian、MA Ke、CHEN Qi、ZHANG Donghui、LIU Runhui
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State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,P.R.China
Key Laboratory for Ultrafine Materials of Ministry of Education,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Research Center for Biomedical Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,P.R.Chi
School of Biotechnology,East China University of Science and Technology,Shanghai 200237,P.R.China
National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Sailing Program,ChinaFund of the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education ComResearch Center of Analysis and Test of East China University of Science and Technology
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