Abstract
Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic stability.One type of polypeptoids,poly-N-methoxyethylglycine(P-Nmeg),has been found to possess remarkable hydrophilicity and notable properties in terms of protein,cell,and bacterial antifouling.However,the currently known synthesis methods of P-Nmeg include solid-phase synthesis,which is time-consuming and difficult to scale up,and N-substituted N-carboxyanhydride(NNCA)ring-opening polymerization,whose monomers were difficult to store.In this study,we used the chemical stable Nmeg N-phenoxycarbonyl(NPC)as the monomer,which was obtained without the use of highly toxic reactants,such as phosgene or phosphorus halide,to synthesize P-Nmeg under open-vessel conditions.By adding BnNH2 as an initiator at 80 ℃,we can obtain controllable short chain length P-Nmeg with narrow dispersity.
基金项目
National Key Research and Development Program of China(2022YFC2303100)
National Natural Science Foundation of China(22075078)
National Natural Science Foundation of China(22205063)
Shanghai Sailing Program,China(22YF1410100)
Fund of the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Com()
Research Center of Analysis and Test of East China University of Science and Technology()
NETL
NSTL
维普
万方数据