首页|Regulation of Tumor Microenvironment Under Malignant Conditions:Application of nMOFs in Sonodynamic Therapy

Regulation of Tumor Microenvironment Under Malignant Conditions:Application of nMOFs in Sonodynamic Therapy

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In this review,we delve into the intricate regulation of the tumor microenvironment(TME)under malignant conditions and explore the transformative potential of nanoscale metal-organic frameworks(nMOFs)in the realm of sonodynamic therapy(SDT).The THE serves as a dynamic milieu influencing tumor progression and therapeutic response,presenting formidable challenges,such as hypoxia,acidity,excess hydrogen peroxide,high expression of glutathione,and immunosuppression.Utilizing the exceptional attributes of nMOFs,including their tunable structures and biocompatibility,holds immense promise for enhancing SDT efficacy and reshaping the THE landscape.By integrating nMOFs with SDT,researchers aim to assemble multiple functionalities in a single platform that enhance tumor cell eradication while counteracting unfavorable THE conditions and immune resistance.The potential of nMOFs to revolutionize tumor therapies by precisely targeting THE and overcoming therapeutic barriers is underscored by an in-depth analysis of recent breakthroughs in the use of nMOFs-based sonosensitizers to remodulate THE to amplify the efficacy of SDT.

Sonodynamic therapyMetal-organic frameworkTumor microenvironmentModification of sonosensitizer

YANG Yilin、YAN Fei、SHI Zhan

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State Key Laboratory of Inorganic Synthesis and Preparative Chemistry,College of Chemistry,Jilin University,Changchun 130012,P.R.China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFund of'111 Center',ChinaProgram for JLU(China)Science and Technology Innovative Research Team(JLUSTIRT)

2227111482170154B17020

2024

10.1007/s40242-024-4108-3

高等学校化学研究(英文版)
吉林大学

高等学校化学研究(英文版)

CSTPCD
影响因子：0.871
ISSN：1005-9040
年,卷(期)：2024.40(4)