Abstract
In this review,we delve into the intricate regulation of the tumor microenvironment(TME)under malignant conditions and explore the transformative potential of nanoscale metal-organic frameworks(nMOFs)in the realm of sonodynamic therapy(SDT).The THE serves as a dynamic milieu influencing tumor progression and therapeutic response,presenting formidable challenges,such as hypoxia,acidity,excess hydrogen peroxide,high expression of glutathione,and immunosuppression.Utilizing the exceptional attributes of nMOFs,including their tunable structures and biocompatibility,holds immense promise for enhancing SDT efficacy and reshaping the THE landscape.By integrating nMOFs with SDT,researchers aim to assemble multiple functionalities in a single platform that enhance tumor cell eradication while counteracting unfavorable THE conditions and immune resistance.The potential of nMOFs to revolutionize tumor therapies by precisely targeting THE and overcoming therapeutic barriers is underscored by an in-depth analysis of recent breakthroughs in the use of nMOFs-based sonosensitizers to remodulate THE to amplify the efficacy of SDT.
基金项目
National Natural Science Foundation of China(22271114)
National Natural Science Foundation of China(82170154)
Fund of'111 Center',China(B17020)
Program for JLU(China)Science and Technology Innovative Research Team(JLUSTIRT)()
NETL
NSTL
万方数据