Stereo-control on Lanthanide Triple-stranded Helicates Toward Enhanced Enantioselective Sensing

GUO Xiaoqing ¹ZHANG Xinyuan ²HU Shaojun ¹ZHOU Lipeng ¹SUN Qingfu²

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作者信息

1. State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,P.R.China
2. State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,P.R.China;University of Chinese Academy of Sciences,Beijing 100049,P.R.China
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Abstract

Chiral metal-organic cages(MOCs)serve as a representative model for enzyme simulation,offering a robust platform for reproducing and expanding enzyme functions at the molecular level.In this study,we present a family of lanthanide triple-stranded helicates with finely-tuned stereoconfigurations,self-assembled from ligands featuring both point and axial chiral centers.Circular dichroism(CD)and circularly polarized luminescence(CPL)spectroscopy demonstrated that peripheral point chirality induces the stereoconfiguration(Δ/Λ)of the metal center,while bridging axial chirality defines the cavity chiral microenvironment,resulting in the formation of both homochiral and mesomeric helicates.In comparison to mesocate,the homochiral helicates exhibited heightened enantioselectivity in the luminescent detection of D/L-leucinol.

Key words

Metal-organic cage/Stereocontrolled self-assembly/Lanthanide helicate/Chiral sensing

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基金项目

National Key Research and Development Program of China(2021YFA1500400)

National Key Research and Development Program of China(2022YFA1503300)

National Natural Science Foundation of China(22201285)

National Natural Science Foundation of China(21825107)

National Natural Science Foundation of China(22171264)

出版年

2024

高等学校化学研究(英文版)

吉林大学

高等学校化学研究(英文版)

CSTPCD

影响因子：0.871

ISSN：1005-9040

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