首页|Sandpaper-templated Stretchable Immunosensing Electrodes for Sub-picomolar Progesterone Detection
Sandpaper-templated Stretchable Immunosensing Electrodes for Sub-picomolar Progesterone Detection
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Female hormone detection,particularly non-invasive monitoring progesterone(P4)levels in body fluids,plays a critical role in female health management and disease diagnosis.However,the challenge still exists because of the ultralow abundance of P4(＜100 pmol/L)in sweat and saliva,necessitating highly sensitive methods for wearable detection.Herein,we present a simple sandpaper-templated stretchable immunosensing electrode designed for ultra-sensitive detection of P4 at sub-picomolar level.A molding technique is employed to replicate the sandpaper textures to provide a microstructured elastomeric substrate for electrode preparation.Such microstructured surface coated with poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate)(PEDOT:PSS)/LiTFSI[LiTFSl=lithium bis(trifluoromethanesulfonyl)imide]provided a stretchable polymer electrode with high conductivity,and further decoration with gold nanoparticles(AuNPs)enabled the immunosensing for P4 by electrochemical impedance spectroscopy(EIS)measurements.Through adjusting the AuNPs deposition conditions,ultrasensitive detection of P4 is realized with a low limit of detection(LOD)of ca.10 fmol/L and a tunable dynamic range up to μmol/L.Notably,the stretchable electrode exhibits stable electrochemical performance,enabling the detection of P4 at sub-picomolar levels even under mechanical strain of 30％.This innovative electrochemical sensor holds significant promise for non-invasive,on-site monitoring of P4 levels in healthcare,as well as hormone detection in food safety and environment surveillance.
LI Zhaoxian、MENG Xingyu、FANG Chuyao、YI Zhenkai、WU Yaoyao、LIU Xuanxuan、ZHONG Wei、ZHANG Limei、XIE Zhuang
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School of Materials Science and Engineering,Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education,Sun Yat-sen University,Guangzhou 510275,P.R.China
Reproductive Medicine Center,Department of Obstetrics and Gynecology,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,P.R.China
National Natural Science Foundation of ChinaFundamental Research Funds for the Central Universities,Sun Yatsen University,China
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