Serum MBL,IL-1R1,and Nrf2 levels and their correlations with pulmonary function and prognosis in children with asthma induced by mycoplasma pneumoniae infection
Objective To explore the correlation between serum levels of mannose-binding lectin(MBL),in-terleukin-1 receptor type 1(IL-1R1),and nuclear factor E2-related factor 2(Nrf2)with pulmonary function in chil-dren with asthma induced by mycoplasma pneumoniae(MP)infection,and to analyze the relationship between these bio-markers and the prognosis of the affected children.Methods A total of 126 children with asthma induced by MP infec-tion(Asthma group)admitted to the Shijiazhuang Medical College Affiliated Hospital from February 2020 to February 2023 were enrolled.Additionally,126 healthy children(Healthy group)and 126 children with Mycoplasma pneumoniae pneumonia(MPP group)were included as controls.Serum levels of MBL,IL-1R1,and Nrf2 were measured,along with pulmonary function parameters,including forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),FEV1/FVC ratio,and peak expiratory flow(PEF)as a percentage of predicted values(PEF％pred).Pearson correlation analysis was used to assess the relationships between serum levels of MBL,IL-1R1,Nrf2,and pulmonary function.Multivariate logistic regression was performed to analyze the factors influencing prognosis in children with MP-induced asthma.Receiver operating characteristic(ROC)curves were used to evaluate the predictive value of serum MBL,IL-1R1,and Nrf2 for poor prognosis.Results Serum MBL and IL-1R1 levels were significantly higher in the Asthma group compared to the MP infection and Healthy groups,while serum Nrf2 levels,FEV1,FVC,FEV1/FVC,and PEF％pred were lower in the Asthma group.Serum Nrf2 levels were positively correlated with FEV1,FVC,FEV1/FVC,and PEF％pred(r=0.484,0.521,0.569,0.481;P＜0.001),while serum MBL and IL-1R1 were negatively corre-lated with these pulmonary function parameters(r=-0.531,-0.533,-0.611,-0.545,-0.549,-0.564,-0.574,-0.597;P＜0.05).The rate of poor prognosis in the Asthma group was 37.30％.Logistic regression analysis revealed that a history of allergies,high serum levels of MBL and IL-1R1,and low serum levels of Nrf2 were independ-ent risk factors for poor prognosis in children with MP-induced asthma(P＜0.05).The area under the ROC curve(AUC)for the combined prediction of poor prognosis using serum MBL,IL-1R1,and Nrf2 was 0.880(95％CI:0.810-0.934),which was higher than the AUCs for each individual marker(0.710,0.722,0.743).Conclusion Elevated serum levels of MBL and IL-1R1,and decreased levels of Nrf2 in children with asthma induced by MP infection are sig-nificantly associated with pulmonary function and prognosis.The combined detection of serum MBL,IL-1R1,and Nrf2 holds high predictive value for the prognosis of MP-induced asthma in children.
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