Study on skin barrier function in psoriasis vulgaris with spleen deficiency and dampness syndrome
Objective To investigates the changes in skin barrier function in patients with psoriasis vulgaris with spleen deficiency and dampness syndrome and compares them with healthy controls to explore whether the disrupted water metabolism associated with spleen deficiency is clinically related to skin barrier dysfunction in psoriasis.Methods A to-tal of 162 participants were enrolled,including 132 patients diagnosed with spleen deficiency and dampness syndrome pso-riasis vulgaris(case group)and 30 healthy volunteers(control group).Measurements included stratum corneum hydration(SCH),transepidermal water loss(TEWL),and skin pH at the psoriatic lesions,the border between lesions and normal skin,and areas 10 cm away from the lesions.These metrics were compared to those in the control group to assess differ-ences in skin barrier function.Results Compared with healthy controls,psoriatic patients exhibited significantly higher pH values[5.9(5.6,6.1)vs.5.05(4.6,5.4),5.6(5.4,5.9)vs.5.05(4.6,5.4),5.3(5.1,5.6)vs.5.05(4.6,5.4)],increased TEWL[15(13,18)g/hm2 vs.10(9,11)g/hm2,13.5(11,15)g/hm2 vs.10(9,11)g/hm2,11(10,13)g/hm2 vs.10(9,11)g/hm2],and lower SCH[17(14,19)％vs.43(41,44.25)％,21(18,24)％vs.43(41,44.25)％,43(41,44.25)％vs.43(41,44.25)％]at the psoriatic lesions,the border between lesions and horman skin,and areas 10 cm away from the lesions(P＜0.05).SCH at 10 cm from the lesion was significantly higher than at the lesion itself(P＜0.05),while TEWL and pH were significantly lower at 10 cm from the lesion than at the lesion(P＜0.05).Conclusion Psoriasis vulgaris patients with spleen deficiency and dampness syndrome show marked impair-ment of skin barrier function.This highlights the need for clinical efforts to restore skin barrier integrity,potentially allevi-ating psoriatic symptoms such as dryness and pruritus.
spleen deficiency dampness syndromepsoriasisbarrier functionsurvey and research
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