Clinical efficacy of Tongdu Tiaoshen acupuncture combined with Tongue Three-Needle for dysphagia in tuber-culous meningitis
Objective To investigate the efficacy of Tongdu Tiaoshen acupuncture combined with Tongue Three-Needle in treating dysphagia caused by tuberculous meningitis(TBM),providing clinical evidence for its application in managing dysphagia in TBM patients.Methods A prospective study was conducted involving 100 TBM patients with dysphagia treated at Guangzhou Chest Hospital between March 2023 and May 2024.Patients were randomly assigned to an observation group and a control group(50 cases each).The observation group received TBM treatment combined with standard swallowing rehabilitation and acupuncture,while the control group received TBM treatment and standard swallo-wing rehabilitation only.Clinical efficacy was assessed by comparing changes in Kubota drinking test grades and Standard-ized Swallowing Assessment(SSA)scores before and after treatment.The study also examined serum nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),cerebrospinal fluid(CSF)pressure,and surface electromyography(sEMG)of suprahyoid and submental muscle groups to explore the potential mechanisms.Results Using a Kubota drinking test grade of≤Ⅱ as the criterion for cure,the cure rates were significantly higher in the observation group(90％,45/50)than in the control group(68％,34/50)(x2=12.852 5,P=0.000 337).Pre-treatment SSA scores showed no significant differences between groups(Z=-0.575,P=0.565),but post-treatment SSA scores were signif-icantly lower in the observation group than in the control group(Z=-3.330,P=0.001).The improvement in SSA scores was significantly greater in the observation group(Z=-3.339,P=0.001).After treatment,NGF levels were significantly higher in the observation group than in the control group(Z=-6.922,P=0.000),while CSF pressure was lower(Z=-2.735,P=0.006).No significant difference was observed in BDNF levels between groups(Z=-1.820,P=0.068).Both groups exhibited shortened sEMG durations and reduced amplitudes in the suprahyoid and submental muscle groups,with significantly greater changes in the observation group(P＜0.05).Conclusion Tongdu Tiaoshen acupuncture combined with Tongue Three-Needle demonstrates significant efficacy in treating dysphagia in TBM patients.Its mechanism may involve improving the neurochemical microenvironment in the brain and restoring the functionality of swallowing-related muscles.
国家科技期刊平台
NSTL
万方数据
