Study on the correlation between BKV DNA load and renal function impairment in kidney transplant patients
Objective To investigate the relationship between BK virus(BKV)DNA load and the degree of re-nal function impairment in kidney transplant recipients.Methods A retrospective case-control study was conducted on 76 kidney transplant patients with positive BKV infection(BK group)and 83 BKV-negative transplant recipients(con-trol group)at the Seventh People's Hospital of Zhengzhou.Serum biomarkers such as glomerular filtration rate(eGFR),cystatin C(Cys-C),and serum creatinine(Scr)were compared between the two groups at different postoperative time points.BKV-DNA levels were stratified into low-load and high-load subgroups for further analysis.Renal function im-pairment was defined as Scr＞400 μmol/L within three months post-transplant.Multivariate analysis was performed to evaluate factors associated with impaired renal function post-transplant.Results The BK group exhibited significantly lower eGFR and higher Scr and Cys-C levels than the control group at one and three months post-transplant(P＜0.05).Among the BK group,46 patients had low BKV-DNA load,and 30 had high load.Patients with high viral load demonstrated lower eGFR and higher Scr and Cys-C levels compared to the low-load group at one and three months post-transplant(P＜0.05).Multivariate logistic regression identified decreased preoperative hemoglobin,preoperative blood transfusion,external iliac artery anastomosis,warm ischemia time ≥10 minutes,and BKV infection as independent risk factors for renal function impairment(P＜0.05).Conclusion BKV infection in kidney transplant recipients significantly increases the risk of postoperative renal function impairment.Furthermore,the severity of renal dysfunction correlates with BKV DNA load,emphasizing the importance of early monitoring and management of BKV in this patient population.
kidney transplantationBK virusviral loadrenal function impairmentglomerular filtration ratecystatin Cserum creatinine
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