摘要
目的 了解广东佛山市女性群体人乳头瘤病毒(HPV)感染类型情况.方法 收集佛山复星禅诚医院2019-2021年进行HPV分型检测的21 752例女性健康体检者及门诊人群,利用聚合酶链反应(PCR)-反向斑点杂交法进行HPV感染检测,记录HPV亚型感染情况、年龄及临床诊断.结果 2019-2021年佛山地区女性群体HPV总体感染为20.86％,HPV52、58、16、51、68、53亚型感染最为常见,以单一感染为主.体检和门诊人群中感染率分别为14.68％和23.47％.2019、2020及2021年体检及门诊女性人群HPV的总体感染率分别为25.16％、19.59％和18.51％.不同年龄HPV感染率均呈"U"型.阴道炎和宫颈炎女性患者年龄段大多在25～36岁,以HPV52、16、58和51亚型引起的单一感染为主.宫颈上皮内瘤变(cervical intraepi-thelial neoplasia,CIN)好发于46～55年龄段,以单一感染HPV为主.结论 2019-2021年佛山市女性HPV感染模式具有明显的年龄差异,3年感染率逐年下降,HPV52、58、16、51、68、53亚型感染及单一感染较为常见.HPV 16、18、52、53、L6亚型与宫颈疾病之间呈正相关.
Abstract
Objective To investigate the types of human papillomavirus(HPV)infections in the female popula-tion of Foshan,Guangdong.Methods A total of 21 752 samples from women undergoing health examinations or outpa-tient visits at Foshan Fosun Chancheng Hospital from 2019 to 2021 were analyzed.HPV genotyping was performed using polymerase chain reaction(PCR)-reverse dot blot hybridization.HPV subtypes,patient age,and clinical diagnoses were recorded.Results The overall HPV infection rate among women in Foshan during 2019-2021 was 20.86％,with HPV 52,58,16,51,68,and 53 being the most prevalent subtypes.Single infections were predominant.Infection rates among health examination and outpatient populations were 14.68％and 23.47％,respectively.The annual HPV infection rates for 2019,2020,and 2021 were 25.16％,19.59％,and 18.51％,respectively.HPV infection showed a"U-shaped"distribution across age groups.Vaginitis and cervicitis were most common in women aged 25-36 years,with sin-gle infections caused by HPV 52,16,58,and 51 subtypes.Cervical intraepithelial neoplasia(CIN)was most prevalent in women aged 46-55 years,also with predominantly single infections.Conclusion HPV infection patterns in women from Foshan between 2019 and 2021 demonstrated significant age-related differences,with a decreasing trend in infection rates over the three years.HPV 52,58,16,51,68,and 53 were the most common subtypes,and single infections were predominant.Subtypes HPV 16,18,52,53,and L6 were positively correlated with cervical diseases.
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