Molecular epidemiology of human papillomavirus infection among women in Foshan
Objective To investigate the types of human papillomavirus(HPV)infections in the female popula-tion of Foshan,Guangdong.Methods A total of 21 752 samples from women undergoing health examinations or outpa-tient visits at Foshan Fosun Chancheng Hospital from 2019 to 2021 were analyzed.HPV genotyping was performed using polymerase chain reaction(PCR)-reverse dot blot hybridization.HPV subtypes,patient age,and clinical diagnoses were recorded.Results The overall HPV infection rate among women in Foshan during 2019-2021 was 20.86％,with HPV 52,58,16,51,68,and 53 being the most prevalent subtypes.Single infections were predominant.Infection rates among health examination and outpatient populations were 14.68％and 23.47％,respectively.The annual HPV infection rates for 2019,2020,and 2021 were 25.16％,19.59％,and 18.51％,respectively.HPV infection showed a"U-shaped"distribution across age groups.Vaginitis and cervicitis were most common in women aged 25-36 years,with sin-gle infections caused by HPV 52,16,58,and 51 subtypes.Cervical intraepithelial neoplasia(CIN)was most prevalent in women aged 46-55 years,also with predominantly single infections.Conclusion HPV infection patterns in women from Foshan between 2019 and 2021 demonstrated significant age-related differences,with a decreasing trend in infection rates over the three years.HPV 52,58,16,51,68,and 53 were the most common subtypes,and single infections were predominant.Subtypes HPV 16,18,52,53,and L6 were positively correlated with cervical diseases.
human papillomavirusgenotypingepidemiologycervical diseases
国家科技期刊平台
NSTL
万方数据
