Study on the correlations between 25(OH)D levels and blood glucose,islet function,seasons,and solar terms in patients with type 2 diabetes mellitus
Objective To investigate factors influencing serum 25-hydroxyvitamin D[25(OH)D]levels in hospitalized patients with type 2 diabetes mellitus(T2DM),and to analyze its relationship with blood glucose,glycated hemoglobin(HbA1c),insulin,HOMA2-IR,HOMA2-β,HOMA2-IS,seasons,and solar terms.Methods A total of 871 hospitalized T2DM patients from Yueyang Hospital of Integrated Traditional Chinese and Western Medicine between July 2022 and February 2023 were enrolled.Patient demographics(sex,age,BMI,diabetes duration,season,and solar term of disease onset)were recorded.Laboratory measurements included HbA1c,fasting blood glucose(FBG),postpran-dial blood glucose(1-hour and 2-hour),fasting insulin,and C-peptide.The modified HOMA formula was used to calculate HOMA2-IR(insulin resistance),HOMA2-β(β-cell function),and HOMA2-IS(insulin sensitivity).Patients were categorized into four groups based on their 25(OH)D levels:sufficient(＞75 nmol/L),insufficient(50-75 nmol/L),deficient(25-＜50 nmol/L),and severely deficient(＜25 nmol/L).Results BMI,HbA1c,postpran-dial 1-hour glucose,fasting insulin,fasting C-peptide,and HOMA2-IR were negatively correlated with 25(OH)D levels,while HOMA2-β and HOMA2-IS were positively correlated.Significant differences in 25(OH)D levels were observed across different age groups in men and BMI categories in women(P＜0.05).Both men and women had the low-est 25(OH)D levels during spring.Among men,25(OH)D levels peaked at the solar term Bailu and were lowest at Xiao-han;in women,levels were highest at Lidong and lowest at Daxue.Conclusion Hyperglycemia,reduced islet function,age,sex,BMI,seasons,and solar terms are key factors influencing 25(OH)D levels in T2DM patients.These findings provide a reference for preventing and managing osteoporosis in T2DM patients.
type 2 diabetes mellitus25 hydroxyvitamin Dblood sugarislet functionseason
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