摘要
液体活检是一种操作简单的肿瘤标本获取方式,具有微创性、可重复性和易获取性等优点.临床上通过液体活检的方式可以获得相应肿瘤组织的循环肿瘤DNA(circulating tumor DNA,ctDNA).ctDNA是直接来源于肿瘤的无细胞状态DNA,其常携带全面的肿瘤基因信息.研究发现ctDNA的检测可在肿瘤的早期诊断、靶向治疗以及预测复发中发挥作用,目前已被批准应用于多种恶性肿瘤的诊治.下文对ctDNA检测这一技术在宫颈癌的早期诊断、指导治疗、疗效评价、预测复发等方面的研究和应用进行综述,为临床工作提供参考.
Abstract
Liquid biopsy is an efficient method for obtaining tumor samples with advantages such as minimal inva-siveness,repeatability,and ease of collection.Through liquid biopsy,circulating tumor DNA(ctDNA),a cell-free DNA directly derived from tumors,can be acquired.This DNA contains comprehensive genetic information specific to the tumor.Studies have shown that ctDNA testing can be instrumental in early cancer diagnosis,targeted therapy,and recur-rence prediction.It has already been approved for use in managing various malignancies.This review provides an overview of ctDNA testing technology in cervical cancer,covering aspects such as early diagnosis,treatment guidance,therapeutic efficacy evaluation,and recurrence prediction,aiming to offer valuable insights for clinical practice.
国家科技期刊平台
NSTL
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