Expressions of Wnt proteins in skin squamous cell carcinoma and basal cell carcinoma
Objective To explore the expression patterns and clinical values of Wnt10a,Wnt10b,Wnt5a,and β-catenin in cutaneous squamous cell carcinoma(SCC)and basal cell carcinoma(BCC).Methods Thirty-three specimens from the patients with SCC and 33 specimens from the patients with BCC pathologically confirmed at Hospital Affiliated to Jiujiang University from January to December 2021 were selected.There were 28 males and 38 females;they were 45-88 years old.The expressions of Wnt10a,Wnt10b,Wnt5a,and β-catenin in the specimens were detected by the immunohistochemical staining.The x2 test was used.Results Wnt10b,Wnt5a,and β-catenin expressed mainly in the cytoplasm and nucleus in both BCC and SCC;the positive expression rates in both tumors were 100.0％.Wnt10a did not expressed in BCC,while the positive rate in SCC was 30.3％(10/33),with a statistical difference(P＜0.05).Conclusions Wnt signaling pathway proteins obviously express in BCC and SCC,indicating that the Wnt signaling pathway plays a significant role in the tumorigenesis and development of BCC.Wnt10a can be used as a molecular marker identifying BCC and SCC.
万方数据
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