Ultrasound-guided local comprehensive intervention therapy for patients with large liver cancer
Objective To observe the effect of ultrasound guided local comprehensive intervention therapy for patients with large liver cancer patients.Methods Ninety-five patients with large liver cancer admitted to First Hospital,Nanyang Medical College from October 2020 to March 2022 were selected for the prospective study.According to the treatment indications,the enrolled patients were divided into a conventional group(45 cases)and an experimental group(50 cases).There were 25 males and 20 females in the conventional group;they were(60.44± 5.23)years old.There were 30 males and 20 females in the experimental group;they were(61.32± 5.17)years old.The conventional group took transcatheter arterial chemoembolization(TACE),while the experimental group took the comprehensive intervention therapy consisting of percutaneous ethanol injection(PEI),radio frequency ablation(RFA),and TACE.All the patients were followed up for one year.The short-term efficacies and long-term survival of the two groups were compared.x2 and t tests were applied.Results The overall response rate(ORR)and disease control rate(DCR)in the experimental group were higher than those in the conventional group[80.00％(40/50)vs.64.44％(29/45)and 90.00％(45/50)vs.77.78％(35/45)],with statistical differences(x2=6.034 and 5.525;both P＜0.05).Before the treatment,there no statistical differences in the levels of liver function indicators between the two groups(all P＞0.05).After the treatment,the levels of alanine transaminase(ALT),glutamic pyruvic transaminase(AST),and total bilirubin(TBil)in the experimental group were lower than those in the conventional group[(50.25±10.17)U/L vs.(56.39±10.47)U/L,(48.24±10.49)U/L vs.(55.16±10.33)U/L,and(15.44±5.28)μmol/L vs.(18.15± 5.41)μmol/L],with statistical differences(t=2.897,3.234,and 2.469;all P＜0.05).After the treatment,the incidence of adverse reactions in the experimental group was 30.00％(15/50),which was slightly higher than that in the conventional group[28.89％(13/45)],with no statistical difference(x2=0.030;P＞0.05).The survival rates in the third,sixth,and twelfth months of the follow up in the experimental group were higher than those in the conventional group[96.00％(48/50)vs.84.44％(38/45),90.00％(45/50)vs.75.56％(34/45),and 86.00％(43/50)vs.68.89％(31/45)],with statistical differences(x2=7.573,7.314,and 8.380;all P＜0.05).The recurrence rates in the third,sixth,and twelfth months of the follow up in the experimental group were lower than those in the conventional group[8.00％(4/50)vs.20.00％(9/45),16.00％(8/50)vs.28.89％(13/45),and 20.00％(10/50)vs.33.33％(15/45)],with statistical differences(x2=5.980,4.773,and 4.543;all P＜0.05).Conclusion Ultrasound-guided local comprehensive intervention therapy for patients with large liver cancer can enhance the treatment effect,effectively improve their long-term survival rate,and reduce recurrence rate,without significantly affecting their liver function or increasing the risk of adverse reactions.
Large liver cancerLocal comprehensive intervention therapyHepatic artery chemoembolizationSurvival ratePrognosis
万方数据
维普
