High flow oxygen therapy in early prone position for patients with pneumonia associated acute respiratory failure
Objective To observe the effect of high flow oxygen therapy in early prone position for patients with severe pneumonia related acute respiratory failure and its effect on clinical outcomes.Methods One hundred and twenty-three patients with pneumonia related acute respiratory failure who were treated at Nanyang First People's Hospital from January 2021 to June 2022 were selected as the study objects,and were divided into a control group(61 cases)and an observation group(62 cases)according to the treatment plans they took.There were 36 males and 25 females in the control group;they were(65.25±5.47)years old.There were 38 males and 24 females in the observation group;they were(66.14±5.28)years old.The control group took routine high-flow oxygen therapy,and the observation group took high-flow oxygen therapy in early prone position.The lung ventilation function and oxygenation function 3 and 7 d after the treatment,treatment status,and clinical outcomes were compared between the two groups.x2 and t tests were used.Results Under different treatment regimens,the percentage of forced expiratory volume in the first second(FEV1),maximal ventilatory volume(MW),and volume of alveolar ventilation(VA)3 d after the treatment in the observation group were higher than those in the control group[(78.25±5.33)％vs.(75.11±5.28)％,(81.44±5.25)％vs.(78.24±5.36)％,and(3.63±0.26)L/min vs.(2.77±0.24)L/min];the FEV1,MW,and VA 7 d after the treatment in the observation group were higher than those in the control group[(83.36±5.31)％vs.(81.35±5.28)％,(85.45±5.26)％vs.(82.49± 5.18)％,and(4.03±1.21)L/min vs.(3.26±1.19)L/min].The oxygen partial pressure(PaO2),oxygen saturation(SaO2),and oxygenation index(P/F)3 d after the treatment in the observation group were higher than those in the control group[(78.82±8.64)mmHg(1 mmHg=1.333 kPa)vs.(75.11± 8.33)mmHg,(94.36±5.26)％vs.(92.11±5.17)％,and(425.33±20.47)mmHg vs.(411.35± 20.36)mmHg];the PaO2,SaO2,and P/F 7 d after the treatment in the observation group were higher than those in the control group[(84.37±10.29)mmHg vs.(79.44±10.77)mmHg,(97.24±3.36)％vs.(95.22±3.31)％,and(492.45±40.65)mmHg vs.(471.35±40.28)mmHg].After the treatment,the tracheal intubation rate,oxygen inhalation time,and length of ICU hospitalization in the observation group were lower than those in the control group[19.35％(12/62)vs.32.79％(20/61),(45.33± 10.36)min vs.(50.44±10.27)min,and(5.25±1.31)d vs.(6.77±1.61)d],with statistical differences(all P＜0.05).After the treatment,the incidence of adverse reactions in the observation group was 11.29％(7/62),and that in the control group was 9.84％(6/61),with no statistical difference(P＞0.05).The mortality rate within one month in the observation group was lower than that in the control group[3.23％(2/62)vs.18.03％(11/61);P＜0.05].Conclusion High flow oxygen therapy in early prone position for patients with pneumonia related acute respiratory failure can promote their recovery of ventilation and oxygenation function,and has positive significance in optimizing their diagnosis and treatment and improving their poor prognosis.
Severe pneumoniaAcute respiratory failureEarly prone positionHigh flow oxygen therapyClinical outcomes
万方数据
维普
