Meta-analysis of butorphanol and tramadol on chills and safety in puerperae undergoing cesarean section under combined spinal-epidural anesthesia
Objective To evaluate the effects of butorphanol tartrate and tramadol on the control of chills and the incidence of adverse reactions such as nausea and vomiting during cesarean section under combined spinal-epidural anesthesia by using a meta-analysis system.Methods The randomized controlled trials(RCTs)of butorphanol tartrate and tramadol on the control of chills during cesarean section under combined spinal-epidural anesthesia were retrieved from the establishment of Chinese databases such as VIP,Wanfang,and CNKI and English databases such as PubMed,Embase,and Cochrane library to December 2022.Cochrane quality evaluation scale was used to evaluate the quality of the selected literatures,and RevMan 5.3 was used to conduct statistical analysis on the contents of the literatures.Results A total of 15 RCTs including 1 293 patients were included in this meta-analysis.The results of meta-analysis showed that the effective control rate of chills with butorphanol tartrate was higher than that of tramadol[RR=1.07,95％confidence interval(CI)(1.04,1.11),P＜0.000 1],and the incidence of adverse reactions such as nausea and vomiting was lower than that of tramadol[RR=0.13,95％CI(0.09,0.21),P＜0.000 01].Conclusion Butorphanol tartrate can be used to control chills during cesarean section under combined spinal-epidural anesthesia,with less adverse reactions,which is a more effective and safer anesthetic drug.
ButorphanolTramadolCesarean sectionCombined spinal-epidural anesthesiaChillsNausea and vomitingMeta analysis
万方数据
维普
