Study on the therapeutic effect of arthroscopic debridement combined with osteotomy for medial compartment knee osteoarthritis
Objective To study the therapeutic effect of arthroscopic debridement combined with osteotomy for medial compartment knee osteoarthritis.Methods A prospective study was conducted.Fifty-eight patients with medial compartment knee osteoarthritis admitted to Linyi Traditional Chinese Medical Hospital from February 2020 to August 2021 were randomly divided into an observation group and a control group by drawing lots,with 29 cases in each group.In the observation group,there were 17 males and 12 females,aged(41.12±5.84)years.In the control group,there were 19 males and 10 females,aged(40.87±6.02)years.The control group underwent arthroscopic debridement,and the observation group underwent combined osteotomy on the basis of the control group.The perioperative indexes were compared between the two groups,including the Visual Analogue Scale(VAS)score,Hospital for Special Surgery(HSS)knee score,American Knee Society Score(AKSS),Western Ontario and McMaster University(WOMAC)osteoarthritis index,levels of interleukin(IL)-17,matrix metalloproteinase-3(MMP-3),and MMP-9 in serum and synovial fluid,and incidence of complications.t test and x2 test were used.Results In the observation group,the operation time and postoperative VAS score,HSS score,AKSS score,and WOMAC score were(72.68±7.64)min,(2.56±0.52)points,(89.06±10.23)points,(86.24±9.85)points,and(16.24±2.86)points,and those in the control group were(50.46±6.87)min,(3.12±0.43)points,(78.69±9.93)points,(75.95±7.86)points,(20.57±3.35)points,with statistically significant differences(t=11.646,4.469,3.917,4.397,and 5.294;all P＜0.001).The postoperative serum levels of IL-17,MMP-3,and MMP-9 in the observation group were(4.03±1.12)ng/L,(98.97±18.76)pg/L,and(29.86±6.47)μg/L,and those in the control group were(4.96±1.09)ng/L,(146.96±19.15)μg/L,and(38.87±7.54)μg/L,with statistically significant differences(t=3.205,9.640,and 4.884;all P＜0.001).The postoperative synovial fluid levels of IL-17,MMP-3,and MMP-9 in the observation group were(5.35±1.21)ng/L,(102.96±17.84)μg/L,and(36.08±7.94)μg/L,and those in the control group were(6.98±1.14)ng/L,(162.74±18.23)μg/L,and(48.87±8.35)μg/L,with statistically significant differences(t=5.280,12.621,and 5.978;all P＜0.001).The incidence of postoperative complications was 10.34％(3/29)in the observation group and 3.45％(1/29)in the control group;with no statistically significant difference(x2=0.269,P=0.604).Conclusion Arthroscopic debridement combined with osteotomy in the treatment of medial compartment knee osteoarthritis can obtain a good therapeutic effect,which can inhibit the inflammatory reaction,reduce the joint pain,and improve the knee joint function.
Knee osteoarthritisArthroscopyOsteotomyInflammatory reactionPainKnee joint function
万方数据
维普
