Observation on the effect of long-term reverse moxibustion on preventing post-stroke depression in patients with acute cerebralinfarction
Objective To observe the effect of long-term reverse moxibustion on preventing post-stroke depression in patients with acute cerebral infarction.Methods This study was a randomized controlled trial.Eighty patients with acute cerebral infarction admitted to Haibin Sanatorium of Jiangsu Province and Lianyungang Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were prospectively selected as the study objects,and were divided into a treatment group(40 cases)and a control group(40 cases)according to the random number table method.In the treatment group,there were 21 males and 19 females,aged(64.55±9.37)years.In the control group,there were 22 males and 18 females,aged(64.58±8.89)years.The control group received standardized treatment for stroke,including anti-platelet aggregation,lipid reduction,and symptomatic treatment for patients with hypertension,diabetes,and coronary heart disease.The treatment group was treated with long-term reverse moxibustion on the basis of the control group,20 min/time,once a day,5 days/week,lasting for 24 weeks.The scores of Hamilton Depression Scale(HAMD),Mini-Mental State Examination(MMSE),Barthel index(BI),and National Institutes of Health Stroke Scale(NIHSS)and the incidence of post-stroke depression were compared between the two groups before treatment and after 4,8,12,and 24 weeks of treatment.Independent sample t test and x2 test were used.Results The incidences of post-stroke depression in the treatment group after 4,8,12,and 24 weeks of treatment were lower than those in the control group[2.5％(1/40)vs.17.5％(7/40),5.0％(2/40)vs.20.0％(8/40),10.0％(4/40)vs.27.5％(11/40),17.5％(7/40)vs.37.5％(15/40)],with statistically significant differences(x2=5.000,4.114,4.021,and 4.013;all P＜0.05).The HAMD scores of the treatment group after 4,8,and 12 weeks of treatment were lower than those of the control group[(7.25±2.88)points vs.(9.07±4.21)points,(9.70±2.74)points vs.(11.28±3.58)points,(12.17±2.76)points vs.(13.85±3.54)points],with statistically significant differences(t=2.261,2.210,and 2.358;all P＜0.05).The MMSE scores of the treatment group after 12 and 24 weeks of treatment were higher than those of the control group[(23.60±1.89)points vs.(22.70±1.83)points,(24.93±1.46)points vs.(23.75±1.63)points],with statistically significant differences(t=2.163 and 3.400,both P＜0.05).The BI scores of the treatment group after 4,8,12,and 24 weeks of treatment were higher than those of the control group[(66.13±6.84)points vs.(62.88±10.35)points,(69.25±4.88)points vs.(65.75±5.26)points,(73.13±4.63)points vs.(70.38±4.58)points,(74.63±3.47)points vs.(71.75±4.46)points],with statistically significant differences(t=2.091,3.087,2.671,and 3.216;all P＜0.05).After treatment,the NIHSS score of the treatment group was lower than that of the control group[(7.20±2.43)points vs.(11.03±2.70)points],with a statistically significant difference(t=6.655,P＜0.05).Conclusion Long-term reverse moxibustion at Baihui and Dazhui points in patients with acute cerebral infarction can promote the recovery of neurological function,improve the cognitive function,and reduce the incidence of post-stroke depression.
Post-stroke depressionCerebral infarctionReverse moxibustionLong course of treatmentPrevention
万方数据
维普
