Effect of Shengshu Sanhuang decoction combined with Zijie Shengji ointment on patients with severe mixed hemorrhoids(damp heat bottom pour type)after surgery
Objective To explore the effect of Shengshu Sanhuang decoction combined with Zijie Shengji ointment on severe mixed hemorrhoids(damp heat bottom pour type)after surgery.Methods This was a randomized controlled trial.A total of 188 patients with severe mixed hemorrhoids(damp heat bottom pour type)who underwent external peeling and internal ligation surgery in Shangqiu Hospital of Traditional Chinese Medicine from January 2021 to February 2023 were prospectively selected as the study objects,and were divided into group A,group B,group C,and group D according to the random number table method,with 47 cases in each group.In group A,22 males and 25 females,aged(45.26±8.32)years,received routine intervention.In group B,21 males and 26 females,aged(46.38±8.59)years,received routine intervention+Shengshu Sanhuang decoction.In group C,20 males and 27 females,aged(47.13±8.67)years,received routine intervention+Zijie Shengji ointment.In group D,23 males and 24 females,aged(45.89±8.45)years,received routine intervention+Shengshu Sanhuang decoction+Zijie Shengji ointment.Clinical indicators and levels of inflammatory factors and anal function before and after treatment were compared among the four groups,and the clinical efficacy and adverse events were compared among the four groups.t test,F test,and SNK-q test were used for the measurement data,and x2 test and rank sum test were used for the count data.Results The pain time,edema time,bloody stool time,anal prolapse time,and wound healing time in group D[(7.15±1.59)d,(7.93±1.76)d,(6.23± 1.38)d,(5.98±1.33)d,and(11.56±2.57)d]were shorter than those in group A[(8.97±1.99)d,(9.78± 2.17)d,(7.82±1.74)d,(7.45±1.66)d,and(16.16±3.59)d],group B[(8.06±1.79)d,(8.86±1.97)d,(7.05±1.57)d,(6.73±1.51)d,and(14.39±3.24)d],and group C[(7.93±1.76)d,(8.75±1.94)d,(6.91± 1.54)d,(6.65±1.48)d,and(13.38±2.97)d],with statistically significant differences(all P＜0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)and anal high-pressure zone length in the four groups were all lower than those before treatment,while the anal canal systolic blood pressure and anal canal resting pressure were both higher than those before treatment,with statistically significant differences(all P＜0.05).After treatment,the levels of hs-CRP and TNF-α and anal high-pressure zone length in group D[(11.15± 2.48)mg/L,(25.12±5.58)ng/L,and(2.47±0.54)cm]were lower than those in group A[(16.56± 3.68)mg/L,(32.78±7.28)ng/L,and(3.0 5±0.68)cm],group B[(13.17±2.93)mg/L,(2 8.56±6.3 5)ng/L,and(2.77±0.62)cm],and group C[(12.56±2.79)mg/L,(27.88±6.21)ng/L,and(2.72±0.61)cm],with statistically significant differences(all P＜0.05).After treatment,the anal canal systolic blood pressure and anal canal resting pressure in group D[(135.86±30.19)mmHg(1 mmHg=0.133 kPa)and(60.72±13.49)mmHg]were higher than those in group A[(111.38±24.75)mmHg and(49.76± 11.06)mmHg],group B[(122.45±27.19)mmHg and(54.62±12.14)mmHg],and group C[(123.57± 27.46)mmHg and(55.35±12.31)mmHg],with statistically significant differences(all P＜0.05).The total effective rate of group D[95.74％(46/47)]was higher than that of group A,B,and C[70.21％(33/47),80.85％(38/47),and 82.98％(39/47)],with statistically significant differences(all P＜0.05).There was no statistically significant difference in the incidence of adverse events among the four groups(P＞0.05).Conclusion Shengshu Sanhuang decoction combined with Zijie Shengji ointment has definite postoperative effect on patients with severe mixed hemorrhoids(damp heat bottom pour type)after surgery,which can effectively relieve the clinical symptoms,reduce the levels of inflammatory factors,and improve the anal function,with high safety.
Mixed hemorrhoidsDamp heat bottom pour typeShengshu Sanhuang decoctionZijie Shengji ointment
万方数据
维普
