Effect of intestinal preparation-free on recovery and intestinal function in patients after thoracoscopic radical surgery for lung cancer
Objective To observe the effect of intestinal preparation-free on recovery and intestinal function in patients after thoracoscopic radical surgery for lung cancer.Methods This was a randomized controlled trial.A total of 122 patients with lung cancer admitted to the First Afiliated Hospital of Nanyang Medical College from January 2021 to March 202 3 were included.The enrolled patients were divided into a conventional group(61 cases)and an experimental group(61 cases)by the random number table method.In the conventional group,there were 40 males and 21 females,aged 48-72(60.32±5.25)years.In the experimental group,there were 41 males and 20 females,aged 50-70(61.42±5.31)years.All patients underwent thoracoscopic radical surgery for lung cancer.The conventional group received compound polyethylene glycol electrolyte powder for preoperative intestinal preparation,while the experimental group did not take preoperative intestinal preparation measures.The postoperative recovery,postoperative changes in gastrointestinal function and inflammatory indexes,occurrence of gastrointestinal adverse reactions,and surgical safety were compared between the two groups.X2 test and t test were used.Results Under different treatment schemes,the operation time of the experimental group was(170.44± 20.35)min,which was slightly longer than that of the conventional group[(167.35±20.46)min],with no statistically significant difference(P＞0.05);the postoperative exhaust time,defecation time,and hospitalization time of the experimental group were(20.25±5.14)h,(23.36±5.42)h,and(8.76± 2.47)d,which were shorter than those of the conventional group[(23.77±5.18)h,(26.62±5.41)h,and(10.36±3.22)d],with statistically significant differences(all P＜0.05).Before operation,there were no statistically significant differences in the gastrointestinal function indexes between the two groups(both P＞0.05).Under different treatment schemes,the levels of gastrin(GAS)and motilin(MLT)in the experimental groups were(70.22±10.37)ng/L and(78.45±10.27)ng/L,which were lower than those in the conventional group[(75.45±10.26)ng/L and(86.33±10.28)ng/L],with statistically significant differences(both P＜0.05).Before treatment,there were no statistically significant differences in the inflammatory indexes between the two groups(both P＞0.05).Under different treatment regimens,the levels of C-reactive protein(CRP)and interleukin-6(IL-6)in the experimental group were(15.45±4.49)mg/L and(12.33±3.47)ng/L,which were lower than those in the conventional group[(18.77±4.18)mg/L and(15.66±4.14)ng/L],with statistically significant differences(both P＜0.05).Under different treatment schemes,the incidence of gastrointestinal adverse reactions in the experimental group was 8.20％(5/61),which was lower than that in the conventional group[21.31％(13/61)],with a statistically significant difference(P＜0.05);the incidence of surgery-related complications in the experimental group was 9.84％(6/61),which was slightly higher than that in the conventional group[8.20％(5/61)],with no statistically significant difference(P＞0.05).Conclusions Preoperative intestinal preparation-free can accelerate the postoperative rehabilitation process in patients undergoing thoracoscopic radical surgery for lung cancer,and has positive significance in avoiding postoperative gastrointestinal dysfunction and inflammatory reactions and reducing the risk of gastrointestinal adverse reactions.Compared with traditional preoperative intestinal preparation measures,intestinal preparation-free does not significantly increase the risk of surgery-related complications,and has high application value.
Thoracoscopic radical surgery for lung cancerPreoperative intestinal preparationPostoperative recoveryGastrointestinal functionSurgicalrisk
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