Effect of sodium nitroprusside on clinical signs and prognosis of hypertensive crisis patients
Objective To observe the effect of sodium nitroprusside on the clinical signs and prognosis of hypertensive crisis patients.Methods This was a randomized controlled trial.A total of 90 hypertensive crisis patients admitted to the First People's Hospital of Nanyang City from March 2020 to May 2022 were included.The enrolled patients were divrided into an observation group(45 cases)and a control group(45 cases)by the random number table method.In the observation group,there were 25 males and 20 females,aged 48-72(60.48±5.17)years.In the control group,there were 23 males and 22 females,aged 50-70(61.32±5.21)years.The control group was treated with urapidil on the basis of conventional treatment,and the observation group was treated with sodium nitroprusside on the basis of conventional treatment until the blood pressure control reached the standard.The changes of basic signs and cardiac function before and after treatment,and the recovery time of clinical symptoms and medication safety after treatment were compared between the two groups.All patients were followed up for 1 year to compare the prognosis of the two groups.x2 test and t test were used.Results Before administration(T0),ther were no statistically significant differences in the blood pressure and cardiac function between the two groups(all P＞0.05).After 10 min of administration(T1),the systolic blood pressure(SBP)and diastolic blood pressure(DBP)in the observation group were(185.33±20.46)mmHg(1 mmHg=0.133 kPa)and(131.42±20.77)mmHg,which were lower than those in the control group[(197.45± 20.18)mmHg and(145.33±20.42)mmHg],with statistically significant differences(both P＜0.05);the left ventricular ejection fraction(LVEF)of the observation group was higher than that of the control group[(48.72±10.33)％vs.(42.14±10.36)％],but the left ventricular end-diastolic diameter(LVDD)was lower than that of the control group[(50.25±10.37)mm vs.(56.77±10.41)mm],with statistically significant differences(both P＜0.05).After 30 min of administration(T2),there were no statistically significant differences in the blood pressure and cardiac function between the two groups(all P＞0.05).Under different treatment schemes,the recovery time of physical signs of the observation group was(12.33±3.41)min,the improvement time of cardiac function was(20.24± 5.12)min,and the auxiliary ventilation time was(3.44±0.27)h,which were shorter than those of the control group[(14.49±3.15)min,(23.19±5.41)min,and(4.18±1.25)h],with statistically significant differences(all P＜0.05).Under different treatment regiments,the incidence of drug-related adverse reactions in the observation group was 8.89％(4/45),and the incidence of cardiovascular adverse events during follow-up was 11.11％(5/45),which were lower than those in the control group[22.22％(10/45)and 26.67％(12/45)],with statistically significant differences(both P＜0.05).Conclusion Sodium nitroprusside can rapidly improve the basic signs and cardiac function of hypertensive crisis patients and accelerate the patients'rehabilitation process,with drug safety,which can improve the patients'prognosis to a certain extent.
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维普
