Research progress on relationship between iron death and chemotherapy resistance in patients with breast cancer
As a common malignant tumor in women,breast cancer has risen to the top of female malignant tumors,and has serious impact on women's health.At present,although there are various treatment methods for breast cancer,due to the high degree of malignancy and chemotherapy resistance of patients,the clinical treatment effect is not good,which seriously affects the patients'prognosis and survival.Iron death is a novel form of cell death characterized by intracellular iron overexpression and lipid reactive oxygen species accumulation.Studies have found that iron death is related to the occurrence,development,and evolution of breast cancer,so inducing iron death can inhibit the proliferation and distant metastasis of breast cancer cells,enhance the efficacy of chemotherapy drugs,and reverse the chemotherapy resistance of breast cancer.Therefore,inducing iron death may become a new strategy for clinical treatment of patients with breast cancer.In this paper,the mechanism of chemotherapy resistance and iron death in breast cancer and the research progress in the treatment of patients with breast cancer are reviewed.
Iron deathBreast cancerChemotherapyChemotherapy resistanceProgress
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