Effect of dihydroergotoxine combined with ginkgo biloba extract injection for elderly patients with ischemic cerebrovascular disease
Objective To explore the efficacy and safety of dihydroergotoxine combined with ginkgo biloba extract injection for elderly patients with ischemic cerebrovascular disease.Methods In this prospective study,90 elderly patients with ischemic cerebrovascular disease treated at Department of Neurology,Xi'an Gaoxin Hospital from March 2021 to January 2023 were divided into a control group and an observation group according to the treatment order,with 45 cases in each group.There were 25 males and 20 females in the observation group;they were 67-76(69.72±4.03)years old.There were 22 males and 23 females in the control group;they were 66-78(69.58±4.26)years old.Both groups were routinely treated;in addition,the observation group were treated with dihydroergotoxine and ginkgo biloba extract injection,and the control group with dihydroergotoxine.Both groups were treated for 2 weeks.The hemodynamic and cerebral blood flow indicators(blood low shear viscosity,blood high shear viscosity,and plasma viscosity),brain blood flow indicators(cerebrovascular peripheral resistance and end diastolic blood flow velocity of carotid artery),and scores of National Institute of Health Stroke Scale(NIHSS)and Activities of Daily Living(ADL)after the treatment in both groups were recorded and compared.The clinical efficacies and incidences of adverse reactions were compared between the two groups.x2 and t tests were used.Results After the treatment,the blood low shear viscosity,blood high shear viscosity,and plasma viscosity in the observation group were lower than those in the control group[(7.13±1.21)mPa·s vs.(8.26±1.46)mPa·s,(4.89±0.88)mPa·s vs(5.78±1.04)mPa·s,and(1.59±0.31)mPa·s vs.(1.86±0.34)mPa·s],with statistical differences(t=4.00,4.38,and 3.94;all P＜0.05).The end diastolic blood flow velocity of carotid artery and cerebrovascular peripheral resistance in the observation group were better than those in the control group[(96.48±5.31)cm/s vs.(89.46±4.82)cm/s and(1.68±0.23)kPa·s/ml vs.(1.96±0.25)kPa·s/ml],with statistical differences(t=6.57 and 5.53;both P＜0.05).After the treatment,the scores of ADL and NIHSS in the observation group were better than those in the control group[(69.74±5.19)vs.(56.64±5.33)and(5.12±1.13)vs.(8.18±1.45)],with statistical differences(t=11.81 and 11.17;both P＜0.05).The total effective rate in the observation group was higher than that in the control group[91.11％(41/45)vs.73.33％(33/45)],with a statistical difference(x2=4.87;P＜0.05).There was no statistical difference in the total incidence of adverse reactions during the treatment between the observation group and the control group[6.67％(3/45)vs.8.89％(4/45);x2=0.16;P＞0.05].Conclusion In the treatment of elderly Patients with ischemic cerebrovascular disease,the combination of dihydroergotoxine and ginkgo biloba extract injection demonstrates significant clinical efficacy and good safety.
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维普
