Phosphatidylserine soft capsules and intravascular treatment in treatment of patients with ischemic stroke
Objective To observe the value of phosphatidylserine soft capsules and intravascular treatment(EVT)in the treatment of patients with ischemic stroke.Methods This was a prospective study.One hundred and twenty-three patients with ischemic stroke treated at First Hospital,Nanyang Medical College from January 2021 to January 2023 were selected as the study objects,and were divided into a combined group(63 cases)and a control group(60 cases)by the random number table method.There were 32 males and 28 females in the control group;they were(61.22±5.33)years old.There were 33 males and 30 females in the combined group;they were(60.61±5.11)years old.The control group took routine treatment and EVT.The combined group took phosphatidylserine soft capsules and EVT.The improvement of vascular endothelial cell function,platelet function,and coagulation function and neurological rehabilitation of the two groups were compared.t and x2 tests were applied.Results Before the treatment,there were no statistical differences in vascular endothelial cell injury markers,platelet activity indicators,coagulation indicators,and brain nerve function indicators between the two groups(all P＞0.05).After the treatment,the levels of endothelin-1(ET-1),thrombomodulin(TM),von Willebrand factor(vWF),β-thromboglobulin(β-TG),granule membrane protein CD62P,CD63,D-dimer(D-D),coagulation factor Ⅱ(FV Ⅱ),and coagulation factor Ⅶ(FVⅦ)in the combined group were lower than those in the control group[(50.11±10.26)ng/L vs.(56.28±10.32)ng/L,(30.61±5.37)μg/L vs.(33.49±5.28)μg/L,(90.25±10.33)％vs.(96.27±10.15)％,(15.28±5.17)μg/L vs.(18.33±5.41)μg/L,(56.32±10.41)％vs.(61.55±10.28)％,(10.44±3.65)％vs.(12.41±3.62)％,(188.45±50.61)μg/L vs.(211.27±50.66)μg/L,(122.36±20.61)％vs.(135.44±20.66)％,(105.25±20.71)％vs.(120.33± 20.71)％],with statistical differences(t=3.324,2.998,3.258,3.197,2.802,3.004,2.498,3.514,and 4.037;all P＜0.05).Under different treatment regimens,the scores of National Institutes of Health Stroke Scale(NIHSS)3,7,and 14 after the treatment in the combined group were lower than those in the control group[(25.22±5.17)vs.(28.61±5.47),(21.44±5.28)vs.(24.19±5.26),and(18.45±5.33)vs.(21.32±5.14)],with statistical differences(t=3.534,2.893,and 3.037;all P＜0.05).Conclusion Phosphatidylserine soft capsules assisted with EVT for patients with ischemic stroke can effectively alleviate their vascular endothelial damage,inhibit platelet activity,improve their coagulation function,and promote their recovery of brain nerve function.
Intravascular treatmentIschemic strokePhosphatidylserine soft capsulesVascular endothelial cell functionCoagulation function
万方数据
维普
