Effect of bacterial lysates combined with methylprednisolone on children with bronchopneumonia
Objective To investigate the effect of bacterial lysates combined with methylprednisolone on the lung function,immunoglobulin(Ig),and inflammatory factors in children with bronchopneumonia.Methods A total of 98 children with bronchopneumonia admitted to Xuchang People's Hospital from April 2021 to April 2023 were selected as the research objects,and were randomly divided into a control group(49 cases)and an observation group(49 cases)according to the two-color sphere method.The control group included 25 boys and 24 girls,aged(7.59±1.52)years.The observation group included 27 boys and 22 girls,aged(8.01±1.72)years.The control group was given methylprednisolone treatment,intravenous infusion,1 mg/kg,qd,continuous infusion for 3 days,and on the basis the observation group was given bacterial lysate capsules,3.5 mg/time,qd,oral fasting daily for 10 days.The clinical efficacy,recovery time of clinical symptoms,forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),maximum expiratory flow(PEF),IgA,IgM,IgG,C-reactive protein(CRP),transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),and interleukin-4(IL-4)levels before and after treatment,incidence of adverse reactions were compared between the two groups.t test and x2 test were used.Results After treatment,the total effective rate of the observation group was 97.96％(48/49),which was higher than that of the control group[83.67％(41/49)],with a statistically significant difference(P＜0.05).The recovery time of high fever,cough,shortness of breath,and rales in the observation group were shorter than those in the control group,with statistically significant differences(all P＜0.05).After treatment,the PEF,FVC,and FEV1 levels in the observation group were(3.01±0.48)L/s,(1.56±0.22)L,and(1.39±0.28)L,which were higher than those in the control group[(2.72±0.39)L/s,(1.38±0.19)L,and(1.23±0.18)L],with statistically significant differences(all P＜0.05).After treatment,the levels of IgA,IgM,and IgG in the observation group were(1.35±0.12)g/L,(1.44±0.31)g/L and(10.37±1.68)g/L,which were higher than those in the control group[(1.08± 0.09)g/L,(1.11±0.36)g/L,and(8.35±0.79)g/L],with statistically significant differences(all P＜0.05).After treatment,the levels of TGF-β1,CRP,IL-4,and TNF-α in the observation group were decreased more than those in the control group,with statistically significant differences(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions Bacterial lysates combined with methylprednisolone is effective in the treatment of children with bronchopneumonia,which can improve the lung function,inhibit the expressions of inflammatory factors,and improve the immunity,with good safety.
万方数据
维普
