Application of MEBO in the wound repair for children with large area port-wine stains treated by laser
Objective To observe the effect of moisture exposed burn ointment(MEBO)combined with pulsed dye laser on enhancing the overall treatment effect of large area port-wine stains in children,and to guide the treatment of clinically relevant diseases.Methods This was a randomized controlled trial.A total of 60 children with large area port-wine stains admitted to Hunan Provincial People's Hospital from January 2022 to September 2022 were selected as the research objectives,and were divided into two groups using the random number table method,with 30 cases in each group.There were 12 boys and 18 girls in the control group,with an age of(6.25± 1.02)years old.There were 10 boys and 20 girls in the experimental group,with an age of(6.35± 1.05)years old.The control group received 595 nm pulsed dye laser treatment combined with conventional anti-inflammatory ointment to care for the wound,while the experimental group received 595 nm pulsed dye laser combined with MEBO to care for the wound.The treatment effect,degree of red nevus scar regression[evaluated using the Vancouver Scar Scale(VSS)],degree of pain(evaluated using the International Digital Pain Rating System),and adverse reactions were compared between the two groups.t test,x2 test,and rank sum test were used.Results The total effective rate of the experimental group was higher than that of the control group[96.67％(29/30)vs.70.00％(21/30)],with a statistically significant difference(x2=7.680,P＜0.05).At the end of treatment,the regression degree of nevus scar(VSS score)of the experimental group was lower than that of the control group[(1.25±0.85)points vs.(4.02±1.12)points],with a statistically significant difference(t=10.791,P＜0.05).At the end of treatment,the pain degree of the experimental group was lower than that of the control group[(1.02±0.25)vs.(3.02±0.52)],with a statistically significant difference(t=18.986,P＜0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group[10.00％(3/30)vs.43.33％(13/30)],with a statistically significant difference(x2=8.523,P＜0.05).Conclusion MEBO combined with 595 nm pulsed dye laser can significantly improve the therapeutic effect of large area port-wine stains in children,which facilitates the subsidence of red nevus scar,improves the degree of pain,promotes the children's comfort in the process of treatment,and is safe and reliable.
Large area port-wine stains595 nm pulsed dye laserMoisture exposed burn ointmentWound repairChildren
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