Pathogenic bacteria,drug resistance,and antibiotic use in elderly patients with cerebral infarction and pulmonary infection
Objective To investigate the pathogenic bacteria,drug resistance,and antibiotic use in elderly patients with cerebral infarction and pulmonary infection.Methods A total of 222 elderly patients with cerebral infarction admitted to the Third People's Hospital of Liaocheng from January to June 2023 were selected as the study subjects,including 137 males and 85 females,aged 60-85(71.39±5.47)years.Their morning sputum from deep respiratory tract was collected to identify the pathogenic bacteria by the VITEK®2 Compact system,and the drug resistance was tested by the K-B method.The use of antibiotics was analyzed.Results Among the 222 elderly patients with cerebral infarction,60 patients developed pulmonary infection,with an incidence of 27.03％.A total of 136 strains of pathogenic bacteria were isolated from the 60 patients,including 27(19.85％)strains of Gram-positive bacteria,104(76.47％)strains of Gram-negative bacteria,and 5(3.68％)strains of fungi.The main Gram-positive bacteria had high resistance to erythromycin,penicillin,and ampicillin,but low resistance to linezolid,vancomycin,nitrofurantoin,tigecycline,and tetracycline.Among the main Gram-negative bacteria,Klebsiella pneumoniae had low resistance to cefepime,cefotetan,tobramycin,ceftazidime,cefazolin,and piperacillin;E.coli had high resistance to amikacin,ceftazidime,levofloxacin,piperacillin,ciprofloxacin,gentamicin,and cefazolin,but low resistance to cefuroxime,cefotetan,and piperacillin/tazobactam;Pseudomonas aeruginosa had high resistance to piperacillin/tazobactam and cefazolin,but low resistance to amikacin,cefepime,tobramycin,imipenem,levofloxacin,and cefotetan.Among the 60 patients,55 were treated with antibiotics alone,accounting for 91.67％.Among the antibiotics used,cephalosporins,compound preparations,and quinolones were used most frequently,and the main drugs were piperacillin/tazobactam,levofloxacin,and ceftizoxime.Conclusions Gram-negative bacteria such as Klebsiella pneumoniae,E.coli,and Pseudomonas aeruginosa are main pathogenic bacteria in the sputum of elderly patients with cerebral infarction and pulmonary infection,which are highly resistant to some commonly used drugs.Identification of pathogenic bacteria and drug sensitivity test can help effectively prevent and treat pulmonary infection in elderly patients with cerebral infarction in clinical practice.
ElderlyCerebral infarctionPulmonary infectionPathogenic bacteriaDrug resistanceAntibiotic use
万方数据
维普
