Research progress on mechanism of ferroptosis in Alzheimer's disease
Alzheimer's disease is a neurodegenerative disease characterized by chronic neuroinflammation,and poses a serious medical challenge and burden worldwide.As an iron-dependent form of cell death characterized by iron accumulation,lipid peroxidation,disturbance of amino acid metabolism,and irreversible disruption of the plasma membrane.Ferroptosis may be associated with neurological dysfunction in Alzheimer's disease.This article reviews the role of ferroptosis in the pathologic progression of Alzheimer's disease through iron,lipid,and amino acid metabolisms,and the potential therapeutic measures for inhibiting ferroptosis in Alzheimer's disease.It is expected that ferroptosis will provide new insights into the pathogenesis and preventive treatment of Alzheimer's disease.
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