Tumor microenvironment has many components that play an immunosuppressive role;among which,programmed cell death-ligand 1(PD-L1)is closely related to tumor-associated macrophages(TAMs),and plays a vital role in the occurrence and development of breast cancer.This article reviews the significance of PD-L1 and TAMs in the occurrence and development of breast cancer and the possible interaction mechanism between them,as well as the effects of anti-programmed cell death protein-1(PD-1)/PD-L1 combined with targeting TAMs in the treatment of breast cancer.
关键词
乳腺癌/PD-L1/肿瘤相关巨噬细胞/免疫抑制/肿瘤微环境/进展
Key words
Breast neoplasm/PD-L1/Tumor-associated macrophages/Immunosuppression/Tumor microenvironment/Progress
维普
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