Value of ABUS combined with serum VEGF and CEA in diagnosis of breast cancer
Objective To explore the value of the automated breast ultrasound system(ABUS)combined with vascular endothelial growth factor(VEGF)and carcinoembryonic antigen(CEA)in the diagnosis of breast cancer.Methods From April 2020 to April 2023,210 patients with breast cancer from Shaanxi Provincial Cancer Hospital were selected as an observation group,including 113 cases on the left side and 97 cases on the right side;they were(52.01±5.16)years old.One hundred healthy individuals undergoing physical examination in the same period were selected as a control group;they(51.23±5.03)years old;both sides were examined.Based on the ABUS imaging,the ultrasound characteristics were observed.The serum levels of VEGF and CEA in both groups were detected using enzyme-linked immunosorbent assay and chemiluminescence.t and x2 tests were used.The receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of ABUS combined with serum VEGF and CEA for breast cancer.Results The occurrence rates of worm-eaten sign,convergence sign,and stellate sign in the observation group were significantly higher than those in the control group[82.86％(174/210)vs.23.00％(23/100),76.19％(160/210)vs.20.00％(20/100),and 77.62％(163/210)vs.13.00％(13/100)],with statistical differences(x2=104.778,87.840,and 115.262;all P＜0.001).The serum levels of VEGF and CEA in the observation group were higher than those in the control group[(141.20±17.23)ng/L vs.(112.81±14.14)ng/L and(8.76±2.92)μg/L vs.(3.51±1.17)μg/L],with statistical differences(t=14.335 and 17.312;both P＜0.001).The ROC analysis showed that ABUS combined with serum VEGF and CEA had the highest diagnostic value for breast cancer(AUC=0.981),with a sensitivity of 92.4％and a specificity of 97.0％,which were higher than any single test.Conclusions ABUS combined with serum VEGF and CEA has a high diagnostic value for breast cancer.Compared with single testing methods,its sensitivity and specificity are higher.It can effectively enhance the early detection and accurate diagnosis of breast cancer.
Breast cancerAutomated breast ultrasound systemVascular endothelial growth factorCarcinoembryonic antigenDiagnostic value
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