Distribution and antibiotic resistance analysis of pathogens in alveolar lavage fluid from 2013 to 2022 in some hospital
Objective To explore the distribution of pathogens and the resistance of common pathogens in alveolar lavage fluid samples from Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from 2013 to 2022.Method Using a retrospective survey research method,36 233 alveolar lavage fluid samples in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from 2013 to 2022 were collected,and 11 801 strains of pathogenic bacteria were isolated from the samples.The results of their cultivation and in vitro drug sensitivity tests were analyzed and studied using the WHONET5.6 software.Results A total of 11 801 strains of non-duplicative isolated pathogens were detected in the alveolar lavage fluid samples;of which,69.15％(8 321/11 801)were gram-negative bacteria,2.28％(1 378/11 801)gram-positive bacteria,and 18.57％(2 192/11 801)fungi.Klebsiella pneumoniae(KPN)had a sensitivity of more than 70.00％to amikacin,carbapenems,and tigecycline;Pseudomonas aeruginosa(PAE)had a sensitivity of more than 40.00％to most antibiotics except cotrimoxazole and minocycline;Acinetobacter baumannii(ABA)had a resistance rate more than 75.00％to most antibiotics except minocycline.Among the most important pathogens in KPN,the proportion of Carbapenem-resistant to Klebsiella pneumoniae(CRKPN)increased,and the drug resistance increased.Methicillin-resistant Staphylococcus aureus(MRSA)accounted for a relatively high proportion,and the drug resistance rate was significantly higher than that of Methicillin-susceptible to Staphylococcus aureus(MSSA).The vast majority of Streptococcus pneumoniae(SPN)was Penicillin-susceptible to Streptococcus pneumoniae(PSSP).Conclusion From 2013 to 2022,the pathogenic bacteria isolated from the alveolar lavage fluid specimens in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology mainly included KPN,PAE,ABA and Staphylococcus aureus(SAU);the drug resistance rate of CRKPN was on the rise.Therefore,we should rationally use the drugs to decrease its drug resistance.
Pathogenic bacteriaDurg resistanceBronchoalveolar lavage fluidBacteriaDrug susceptible test
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